01b: Inflammatory Skin Disease Flashcards

1
Q

Thickening of the epidermis is referred to as:

A

Acanthosis

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2
Q

Loss of cell connections in the epidermis is referred to as:

A

Acantholysis

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3
Q

Fluid pockets forming in epidermis (stretches it out) is a process referred to as:

A

Spongiosis

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4
Q

Describe the histology of psoriasiform epidermal hyperplasia.

A

Rete of epidermis extend downward to about the same level

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5
Q

Interface change in which there’s a thick band of leukocytes that extends from base of epidermis, into dermis.

A

Lichenoid interface change

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6
Q

Parakeratosis refers to:

A

Abnormality in which nuclei are retained in stratum corneum

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7
Q

Seborrheic dermatitis: what’s the histopathologic process/change?

A

Subacute spongiosis (in epidermis) with characteristic shoulder parakeratosis (distinctive scaling)

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8
Q

Lichenoid Dermatitis prototype is (X) inflammatory condition, which is characterized by:

A

X = Lichen Planus

5 P’s: Purple, Pruritic, Polygonal, Planar Papules

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9
Q

Vacuolar Dermatitis, such as in (X) disease, will show which histopathologic changes?

A

X = lupus

Lymphocytes at interface (of epidermis and dermis) that cause destruction of cells (cleared areas around cells); thickened BM

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10
Q

Lupus band test looks for:

A

Immune deposits (IgG, A, M, and complement C3)

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11
Q

Pemphigous vulgaris: classic skin finding is (X).

A

X = flaccid bullae (easily disrupted due to intraepidermal pathology)

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12
Q

Bullous Pemphigoid: classic skin finding is (X).

A

X = Tense bullae (subepidermal pathology)

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13
Q

Elderly man with round/oval well-demarcated skin lesions that vary from brown/black to gray and can be scraped off.

A

Seborrheic keratoses

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14
Q

Multiple seborrheic keratoses that erupt at once are associated with which disease? What is the sign called?

A

Visceral cancer;

Sign of Leser-Trélat

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15
Q

Benign proliferations of epidermis caused by (X) infection. They look like seborrheic keratoses, but on finger.

A

Verruca Vulgaris

X = HPV (warts)

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16
Q

27 yo patient presents with tan growth on index finger. With magnification, you see multiple small black dots, which you suspect are (X). Diagnosis?

A

X = thrombosed capillaries

Verruca Vulgaris (HPV wart)

17
Q

Epidermal inclusion (sebaceous) cyst: (soft/firm), subcutaneous, (mobile/immobile) growth derived from (X).

A

Firm, mobile;

X = upper portion of hair follicle epithelium (infundibulum)

18
Q

When suspecting epidermal inclusion cyst, what diagnostic feature should you look for?

A

Central (blackish) punctum

19
Q

Over 90% of (X) cysts are located on the scalp. They are (Y)-colored and can be distinguished from epidermal inclusion cysts by:

A
X = pilar
Y = skin

Lack of central punctum

20
Q

Small white papule on eyelid:

A

Milia (epidermal inclusion cyst contining keratin)

21
Q

17 yo female presents with a brown-colored “mole” on leg that she finds painful. On inspection, it’s smooth, dome-shaped papule. What’s the likely diagnosis?

A

Dermatofibroma

22
Q

You apply lateral pressure on brown-colored, dome-shaped mole, causing a depression. This is called (X) sign and the skin finding is likely:

A

X = dimple or Fitzpatrick’s

Dermatofibroma

23
Q

Papules commonly found grouped on the scrotum and may bleed if traumatized.

A

Angiokeratomas

24
Q

Angiokeratomas may be hallmark of which syndrome?

A

Fabry (alpha galactosidase deficiency)

25
Q

63 yo man with multiple elevated, multi-lobulated, solid papules on forehead. They are white/yellow in color with central depression. Likely diagnosis is:

A

Sebaceous Hyperplasia

26
Q

Sebaceous hyperplasia can be mistaken for:

A

Basal cell carcinoma

27
Q

Bright red/violaceous, dome-shaped papules or tiny macules.

A

Angiomas (dilated capillaries surrounded by endothelial lining)