10.0 Drug List Flashcards Preview

MedST IB: Mechanisms of Drug Action (MoDA) > 10.0 Drug List > Flashcards

Flashcards in 10.0 Drug List Deck (203)
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1

Vesamicol

Non-competative and reversible blocker of VAChT

2

Varenicline

High affinity partial agonist for the α4β2 nAChRs
High affinity full agonst for the α7 nAChRs

3

Trimetaphan

Competative antagonist of the (α3)22)3 isoform of the nAChR

4

Hexamethonium

Competative antagonist of the (α3)22)3 isoform of the nAChR

5

Tetramethylammonium (TMA)

Neuronal (Nn) nAChR agonist 

6

Dimethylphenylpiperazinium (DMPP)

Neuronal (Nn) nAChR agonist 

7

Suxamethonium

Depolarising nAChR antagonist that initially activates the receptor but isnt hydrolysed by AChE so causes a secondary antagonism

8

Curare (d-tubocurarine) 

Non-depolarising nAChR antagonist

9

Pancuronium 

Synthetic non-depolarising aminosteriod nAChR antagonist 

10

Rocuronium 

Synthetic non-depolarising aminosteriod nAChR antagonist 

11

Atracurium

Synthetic non-depolarising nAChR antagonist (benzylisoquinolinium)

12

Mivacurium

Synthetic non-depolarising nAChR antagonist (benzylisoquinolinium)

13

Botulinum toxin (BTx)

Peptidase that cleaves SNARE proteins to prevent release of ACh, hence blocking cholinergic neurotransmission 

14

α-bungarotoxin

Irreversibly binds to the ACh binding site on the adult nAChR hence blocking cholinergic neurotransmission

15

β-bungarotoxin

Inhibits ACh release through a mechanism thought to involve phospholipase A2, which leads to blockage of cholinergic neurotransmission

16

α-lacrotoxin

Causes massive release and subsequent depletion of ACh at the NMJ thought to be due to its ability to form a Ca2+ channel 

17

Tetanus neurotoxin 

Cleaves synaptobrevin to prevent glycine release by inhibitory interneurones upsteam of those innervating skeletal muscle 

18

Bethanechol 

Choline ester that acts as a non-selective agonist of mAChRs 

19

Pilocarpine

mAChR agonist that is stable to hydrolysis by AChE

20

Atropine

Non-selective mAChR antagonist

21

Scopoloamine 

Non-selective mAChR antagonist 

22

Homatropine

Non-selective mAChR antagonist

23

Methscopolamine

Non-selective mAChR antagonist 

24

Ipratropium 

Short-acting non-selective mAChR antagonist (SAMA) with some selectivity for M3 receptors in the airways 

25

Tiotropium

Long-acting non-selective mAChR antagonist (LAMA) with some selectivity for M3 receptors in the airways 

26

Glycopyrronium

Long-acting non-selective mAChR antagonist (LAMA) with some selectivity for M3 receptors in the airways 

27

Tropicamide

Non-selective mAChR antagonist

28

Cyclopentolate 

Non-selective mAChR antagonist 

29

Pirenzepine

M1 selective mAChR antagonist

30

Darifenacin

M3 selective mAChR antagonist