10.5 Small Bowel Flashcards Preview

Pathoma > 10.5 Small Bowel > Flashcards

Flashcards in 10.5 Small Bowel Deck (26)
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1
Q

Duodenal Atresia

A

Failure of the small bowel to canalize

2
Q

What is duodenal atresia associated with?

A

Down Syndrome

3
Q

What are the clinical features of duodenal atresia?

A
  • Polyhydramnios
  • Distension of the stomach and duodenum
  • Bilious vomiting
4
Q

Meckel Diverticulum

A

Outpouching of all 3 layers of the bowel wall due to the failure of the vitelline duct to involute
-> DISEASE OF 2’s

5
Q

Volvulus

A

Twisting of the bowel along its mesentery result in obstruction and infarction

6
Q

What are the common locations of volvulus in the elderly and young adults?

A

Elderly - sigmoid colon

Young adults - cecum

7
Q

Intussusception

A

Telescoping of proximal segment of bowel into a distal segment

8
Q

Lactose Intolerance

A

Decreased function of the lactase enzyme in the brush border that causes dissension and diarrhea with ingestion of milk products

9
Q

Celiac Disease

A

Immune mediated damage of small bowel

10
Q

What is the most pathogenic component of gluten?

A

Gliadin

11
Q

What the pathogenesis of Celiac’s disease?

A

Deaminated gladden is presented by APCs via MHC II and helper T cells mediate tissue damage

12
Q

Dermetitis Herpetiformis

A

Deposition of IgA at tips of dermal papillae - one of the symptoms of Celiac’s disease that resolves with gluten free diet

13
Q

What are the Ab found in Celiac disease?

A

IgA anti-endomysium, tTG or gliadin

14
Q

What will duodenal biopsy show for Celiac disease?

A

Flattening of villi with hyperplasia of the crypts

15
Q

What part of the small intestine is most affected by Celiac disease?

A

Duodenum

16
Q

If there is refractory symptoms in a Celiac patient despite a gluten-free diet what are the possible causes?

A
  • Small bowel carcinoma

- T cell lymphoma

17
Q

Tropical Sprue

A

Damage to small bowel villi by some unknown agent that results in malabsorption - arises after diarrhea and responds to antibiotics

18
Q

Where is the damage mostly seen in tropical sprue?

A

Jejunum and ileum

19
Q

Whipple Disease

A

Systemic tissue damage with macrophages loaded with Tropheryma whippelii - organism remains int hem

20
Q

What is the main site affected by Whipple disease?

A

Fat malabsorption and steatorrhea

21
Q

Why does fat malabsorption occur in Whipple disease?

A

Macrophages block chylomicron absorption in the lamina propria

22
Q

Abetalipoproteinemia

A

Autosomal recessive deficiency of apolipoprotein B-48 and B-100 which leads to defective chylomicron and VLDL and LDL formation

23
Q

Carcinoid Tumor

A

Low grade malignancy of neuroendocrine cells

24
Q

What is the most common site for carcinoid tumor?

A

Small bowel

25
Q

What do GI carcinoid tumors often secrete?

A

Serotonin (5-HIAA in the urine)

26
Q

Carcinoid Heart Disease

A

Right sided valvular fibrosis which leads to tricuspid
regurgitation and PV stenosis

  • Occurs with carcinoid metastasis from the GI to the liver

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