12 - autoimmune skin disorders Flashcards Preview

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Flashcards in 12 - autoimmune skin disorders Deck (11)
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1
Q

(autoimmune skin disorders)

  1. lesions are usually what?
  2. most common areas?
A
  1. crusts covering erosions or ulcers
  2. nasal planum, ear pinnae, footpads
2
Q

(autoimmune skin disorders)

  1. usually dx how?
  2. tx?
A
  1. skin biopsy for histo (w/ lab work if systemic signs)
  2. immunosuppressive doses of corticosteroids
3
Q

(pemphigus complex)

  1. dz mech?

resulting in what?

  1. possible lesions?
A
  1. IgG directed at desmosomes

acantholysis of keratinocytes

  1. pustules to superficial or deep erosions to ulcers
4
Q

(pemphigus foliaceus)

  1. most common of the autoimmune disorders
  2. most common areas?
  3. characterized by what lesions?
A
  1. planum, pinnae, footpads (other areas can be affected as well)
  2. pustules (resulting in crusts)

because its pustular, can mimic pyoderma

5
Q

(pemphigus vulgaris)

  1. rare in dogs and cats
  2. deep erosions to basal layer of epidermis
A
6
Q

(pemphigus erythematosus)

  1. considered benign variation of pemphigus folicaceus - why?
A
  1. it affects face only
7
Q

(bullous diseases: bullous pemphigoid)

  1. this is a bullous dz with separation of the epidermis from the dermis
  2. clinically identical to what?
  3. lesions?
A
  1. pemphigus vulgaris
  2. ulcers and crusts
8
Q

(lupus)

  1. mech of dz?
A
  1. presence of Abs against nuclear antigens

2.

9
Q

(Discoid Lupus Erythematosus)

  1. common?
  2. no systemic signs - see what on skin?
  3. distribution?
A
  1. yes (esp in dogs)
  2. crusts and erosions with hypopigmentation
  3. nasal planum, eyelids, footpads, scrotum
10
Q

(Discoid Lupus Erythematosus)

  1. dx?
A
  1. histopath
11
Q

(systemic lupus erthematosus)

  1. cutaneous lesions are extremely variable
  2. dx?
A
  1. histopath, ANA positive