13.1 - Drugs affecting Acid Secretion

Question 1

What are the 3 molecules that can act on parietal cells to upregulate acid secretion? What cells do they act on?

Answer 1

gastrin - CCK-B receptor
Histamine - H2 receptor
ACh - M3 receptor

Question 2

Name a H2 antagonist

Answer 2

Ramitidine. Cimetidine

Question 3

Name H2 antagonist ADRs

Answer 3

diarrhoea, rashes, headache

Question 4

Name 3 example PPIs

Answer 4

Omeprazole, lansoprozole, esomeprazole

Question 5

Give ADRs of PPIs

Answer 5

headache, diarhoea, rashes

Question 6

How do you treat H pylori?

Answer 6

1 week clarithromycin, amoxicilline, omeprazole