2- Connective Tissue Diseases Flashcards Preview

2MB MSK CORTEXT > 2- Connective Tissue Diseases > Flashcards

Flashcards in 2- Connective Tissue Diseases Deck (22)
Loading flashcards...
1
Q

What is the basic pathology behind CTDs?

A

Autoimmunity producing antibodies against cells of the body

2
Q

SLE is more common in whom?

A

Black people

Women 11:1 men

3
Q

Which antibodies are associated with SLE?

A
ANA
Anti-dsDNA
Anti-Sm
Anti-Ro
Anti-La
Anti-RNP
4
Q

Complement levels are high in active SLE. True/False?

A

False

Low

5
Q

Why is urinalysis done in SLE?

A

Look for glomerulonephritis

6
Q

Outline management for mild (skin) SLE

A

Hydroxychloroquine
Topical steroid
NSAID

7
Q

Outline management for moderate SLE

A

Immunosuppression

Steroid

8
Q

Outline management for severe SLE

A

IV steroid

Cyclophosphamide

9
Q

What is the basic pathogenesis in Sjogren’s syndrome?

A

Autoimmune destruction of exocrine glands

10
Q

List clinical features of Sjogren’s syndrome

A

Dry mouth/eyes

Parotid swelling

11
Q

Which autoantibodies are associated with Sjogren’s syndrome?

A

Anti-Ro

Anti-La

12
Q

What is the basic pathogenesis in systemic sclerosis?

A

Excess collagen deposition, causing skin and organ changes

13
Q

What is the difference between limited and diffuse systemic sclerosis?

A

Limited - mainly confined skin changes

Diffuse - rapid skin changes and early organ involvement

14
Q

Which systemic sclerosis - limited or diffuse - is associated with anti-centromere Ab?

A

Limited

15
Q

Which systemic sclerosis - limited or diffuse - is associated with anti-Scl-70 Ab?

A

Diffuse

16
Q

What is a common skin change that occurs in systemic sclerosis?

A

Raynaud’s phenomenon

17
Q

CREST describes findings in systemic sclerosis - what does it stand for?

A
Calcinosis
Raynaud's phenomenon
Oeseophageal dysmotility
Sclerodactyly
Telangiectasia
18
Q

List features of mixed CTD

A
Raynaud's phenomenon
Arthralgia/arthritis
Myositis
Sclerodactyly
Pulmonary hypertension
ILD
19
Q

What does antiphospholipid syndrome increase the risk of?

A

Increased clotting, leading to thrombosis

20
Q

In females, what is the important common consequence of antiphospholipid syndrome (APS)?

A

Pregnancy loss

21
Q

Which immunological factors are associated with APS?

A

Lupus anticoagulant
Anti-cardiolipin antibody
Anti-beta-2-glycoprotein

22
Q

Outline treatment for APS

A

Anticoagulation for those with thrombosis

LMWH in pregnancy