25 APR 2017 0944 MIX Flashcards Preview

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Flashcards in 25 APR 2017 0944 MIX Deck (8)
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1
Q

what is the MOA for dobutamine in severe cardiomyopathy / HF?

A
  • stimulation of B1 receptors
  • increased cAMP in cardiac myocytes
  • enhanced calcium-mediated binding of actin-myosin complex to troponin C (increased contractility)
  • calcium channel activation (increased HR, positive chronotrope)
2
Q

maternal HTN during pregnancy is associated with ____________________ (oligohydramnios / polyhydramnios)

A

oligohydramnios

3
Q

what are the electrolyte disturbances in tumor lysis syndrome?

A
  • increased phosphorous, potassium, uric acid

- decreased calcium (phosphate binds the calcium)

4
Q

what is the preferred agent to increase appetite and weight gain in cancer-associated cachexia?

A

progesterone analogs (megestrol acetate)

5
Q

what is a hampton hump?

A

area of pulmonary infarction due to PE seen on CXR

6
Q

evidence of thrombocytopenia and microangiopathic hemolytic anemia (eg increased levels of indirect biliburin, AST, ALT, lactate dehydrogenase) should always raise suspicion for:

A

TTP

7
Q

TTP is treated emergently with:

A

plasma exchange (glucocorticoids are often added)

8
Q

what is the treatment of choice for adjustment disorder?

A

psychotherapy