4. Gluconeogenesis, entry of different substrates Flashcards
4. Gluconeogenesis. Steps, entry of different substrates, location, regulation, energy balance, importance.
1
Q
What is gluconeogenesis?
A
Gluconeogenesis (GNG) is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates. -Lactate, glycerol,AA (alanine,glutamate,aspartate) , Ru:proprionate (odd b-ox –> succinyl CoA–>TCA)
2
Q
Location, energy balance and importance of GNG:
A
Location: Brain, nerves, RBC, kidney, testis. These tissues are insulin dependent so GNG is very important. Energy balance: Glucose (-6ATP) Glycogen (-7ATP)
3
Q
Where does the different substrate enter?
A
AA enter with pyruvate og oxaloacetate, Propionate also enters with oxaloacetate, Lactate gets DH into pyruvate, glycerol enter in the form of glycerol 3-p and DH into dihydroxy acetone phosphate in the GNG.
4
Q
Steps of the GNG
A
