9-Immunity by B cells and Ab's Flashcards

A lot of repeats in this chapter from previous chapters objectives. I excluded the repeats.

1
Q

What are the functions of Igα and Igβ on the B surface membrane?

A

Their tails transduce the signal of clustering of IgM’s to the inside of the B cell

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2
Q

What is the function of the B cell co-receptor?

A

it delivers the necessary signals needed to activate a naive B cell when IgM clusters form on the surface.

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3
Q

What is the fxn of CR2 of the B cell co-receptor?

A

it recognizes the complement fragments on a pathogen

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4
Q

What is the fxn of CD19 of the B cell co-receptor?

A

acts as the signaling chain of the receptor

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5
Q

What is the fxn of CD81 of the B cell co-receptor?

A

Unknown, but it does act on HepC cell surface receptor

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6
Q

What special type of Ag’s that B cells can react and activate to without the activation from T cells?

A

Thymus Independent (TI) 1 and 2

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7
Q

Where does the stimulus come from for TI 1 Ag’s?

A

They come from innate immunity products like bacterial LPS.

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8
Q

What types of stimuli are TI-2 Ag’s?

A

They are repetitive carbs or proteins present in high density on the microorganism

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9
Q

How does TI-1 Ag’s activate the B cell?

A

Basically it’s a bunch of signals from innate immunity- TLR4, BCR’s and co-receptors

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10
Q

How do TI-2 Ag’s activate the B cell?

A

They act by crosslinking BCR’s and co receptors

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11
Q

What are the 2 main functions of IL-4?

A

It not only causes growth and proliferation of T cells to TH2 cells, but stimulates B cells when they are activated from TH2 cells

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12
Q

Which cytokines from TH2 cells influcnce the B cell to become a plasma cell?

A

IL-5 and IL-6

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13
Q

What to centrocytes in the germinal centers compete for on the follicular dendritic cell?

A

Ag displayed by the FDC

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14
Q

Why must a centrocyte bind the Ag from the FDC and interact with the TH cell to survive?

A

As centrocytes compete with each other, the ones that find a match and bind are prevented from undergoing apoptosis.

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15
Q

Which type, either plasma or resting B cells, have surface Ig’s?

A

Resting B

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16
Q

Which type, either plasma or resting B cells, have surface MHC-II?

A

Resting B

17
Q

Which type, either plasma or resting B cells, secrete high amts of IG’s?

A

Plasma

18
Q

Which type, either plasma or resting B cells, are capable of growth, somatic hypermutation and isotype switching?

A

Resting B

19
Q

Why do immunodeficient pt’s have hyper IgM syndrome?

A

B cells need T cells and their CD40 ligands to undergo isotype switching from IgM to other Ig’s.

20
Q

What is injected to give passive immunity?

A

Preformed Ab’s, antiserum or T cells

21
Q

How does a baby get it’s serum IgG?

A

It crosses the placenta from mom

22
Q

How does a baby get it’s serum IgA?

A

Boob milk from mom

23
Q

How does a baby get it’s serum IgM?

A

Babies make it after birth

24
Q

What happens to all the Ig’s after birth?

A

THEY RISE

25
Q

Where is FcR located?

A

On phahocytic cell- monocytes, macrophages, dendritic cells

26
Q

What does the FcR function as?

A

It facilitates the uptake nad degradation of pathogens by phagocytes and professional APC’s

27
Q

What does the FcR bind to on the pathogen?

A

IgG

28
Q

How does an Ag cause degranulation of mast cells via IgE?

A

IgE is bound to mast cells –> Ag binds to IgE –> degranulation –> allergic response