[A] 1.71 Tumor-induced angiogenesis (capillary incorporation, budding of endothelial cells) Flashcards Preview

Pathology A - General Pathology > [A] 1.71 Tumor-induced angiogenesis (capillary incorporation, budding of endothelial cells) > Flashcards

Flashcards in [A] 1.71 Tumor-induced angiogenesis (capillary incorporation, budding of endothelial cells) Deck (8)
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1
Q

Neoangiogenesis: Overview

A
  • Without angiogenesis - Tumours can’t grow bigger than 1-2mm
  • Used for oxygen, nutrients & metabolite removal
  • New vessels can produce growth factors
  • Opportunity metastasis
2
Q

Neovascularisation

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New vessels budding

3
Q

Vasculogenesis

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Bone marrow-derived endothelial cells form a new vascular network

4
Q

VEGF & FGF: Function

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Produced by neoplastic cells

  • Induces angiogenesis
5
Q

Neoangiogenesis involves a balance of…

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Angiogenic & antiangiogenic factors

  • ↑VEGF
  • ↑ Proteases
  • ↓Thrombospondin-1
6
Q

Antiangiogenic factors: Examples

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  • Angiostatin
  • Endostatin
  • Vasculostatin

Produced by the split of plasminogen, collagen & transthyretin

Can be used as therapy

7
Q

Neoangiogenesis: Characters of the vessels

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  • Abnormal
  • Permeable
  • Dilated
  • Distorted
8
Q

Lymphangiogenesis

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  • Already existing lymphatic vessels are proliferating
  • Inevitable for solid tumour metastasis to lymph nodes

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