Acetominophen(tylenol) Flashcards

0
Q

Acetominophen(Tylenol)

Mechanism

A

COX inhibitor => elevated pain threshold, antipyretic by action on hypothalamic heat regulatory center

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1
Q

Acetominophen(Tylenol)

Class

A

Antipyretic/analgesic

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2
Q

Acetominophen(Tylenol)

Pharmacokinetics

A

Onset: 15-30 min
Peak: 30-120 min
Duration: 3-4 hrs
1/2 life: 1-3 hrs

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3
Q

Acetominophen(Tylenol)

Indications

A
  • fever

- mild- moderate pain

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4
Q

Acetominophen(Tylenol)

Contraindications

A
  • hypersensitivity

- pt with liver desease

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5
Q

Acetominophen(Tylenol)

Side effects

A
  • dizziness
  • abdominal pain
  • hypoglycemia
  • n+v
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6
Q

Acetominophen(Tylenol)

Dose

A

(Adult): 325-650 mg PO q 4-6 hrs prn, max dose 4 g a day

(Pedi): 15mg/kg PO q 4-6 hrs prn, max dose 4 g a day

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7
Q

Acetominophen(Tylenol)

Precautions

A
  • Metabolized by liver- overdose can be toxic
  • doesn’t have anti-platelet aggregation effect
  • doesn’t have peripheral anti-inflammatory effect
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8
Q

Acetominophen(Tylenol)

Drug to drug

A

Chronic excessive use of alcohol increases risk of hepatotoxicity

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