ACLS Drugs Flashcards Preview

Pharm 512 Drugs > ACLS Drugs > Flashcards

Flashcards in ACLS Drugs Deck (28)
Loading flashcards...
1
Q

Indications for epinephrine

A

symptomatic bradycardia, anaphylaxis, cardiac arrest.

2
Q

Epi mechanism of action

A

B1AR stimulation increases chorno, ino, and dromo tropy

B2AR causes bronchodilation in anaphylaxis

3
Q

Precautions with the use of epi

A

Increased myocardial O2 demand, arrhythmias (increased risk with concurrent volatile anesthetic use)

4
Q

Epi dose: IV and continuous infusion

A

1 mg IV Q3-5 min, 2-20 mcg/ min continuous

5
Q

Mechanism of action of vasopressin

A

Increases water reabsorption at the kidney and causes non adrenergic mediated vasoconstriction

6
Q

Vasopressin dose: IV and continuous

A

40 U IV once to replace 1st or 2nd epi dose in ACLS, 0.02-0.04 U/ min continuous for septic shock

7
Q

1/2 life of vasopressin

A

10-20 min

8
Q

Indications for sodium bicarb

A

ph < 7.10, HCO3< 15, hyperkalemia

9
Q

Precautions for sodium bicarb

A

Ensure adequate ventilation because it combines with H+ to form CO2 which could potentiate the acidosis if unable to ventilate; monitor pH an HCO3 levels frequently

10
Q

Sodium bicarb dose: IV and continuous

A

1 mEq/kg IV, 2-5 mEq/kg titrated to pH and HCO3

11
Q

Dobutamine mechanism of action

A

B1AR increases inotropy; B2AR decreases SVR

12
Q

Clinical uses of Dobutamine

A

cardiogenic shock, decompensated heart failure

13
Q

Dobutamine dose: continuous infusion

A

2-20 mcg/kg/min

14
Q

Why can you not mix Dobutamine or Dopamine with sodium bicarb?

A

They are inactivated in alkaline solutions

15
Q

Uses for Atropine and MOA

A

symptomatic bradycardia, RSI, organophosphate poisoning, and when reversing ND - NMB, used with edrophonium to block parasympathomimetic effects

MOA: aCh competitive antagonist- anticholinergic

16
Q

Atropine dose

A

0.5mg q 3-4 min to max of 3 mg

17
Q

Atropine precautions

A

mydriasis (pupil dilation), paradoxical bradycardia at low doses, asystole, hypotension, bronchospasm

18
Q

Adenosine uses and MOA

A

Used for SVT

Stimulate adenosine receptors in heart and vascular sm. muscle to briefly interrupt AV node conduction

19
Q

Adenosine dose

A

6 mg then 12 mg if needed

20
Q

Amiodarone uses and MOA

A

used for VF and pulseless VT

MOA: Non- competitively inhibits A-AR’s and B-AR’s to prolong action potential duration and refractory period

21
Q

Amiodarone dose

A

150-300 mg over 10 min then 150 mg if needed

22
Q

Amiodarone precautions

A

Prolongs QT- torsades, coagulopathies, pulmonary toxicities, CYP450 inhibitor

23
Q

Amiodarone duration of action

A

2 weeks to months after d/c’d

24
Q

Dopamine MOA and uses

A

MOA Stimulate AAR’s and BAR’s to increase HR and SVR

Used in symptomatic bradycardia, distributive shock, ventricular dysfunction

25
Q

Dopamine dose

A

2-20 mcg/kg/min continuous infusion

26
Q

Dopamine precautions

A

Tissue necrosis if infiltrates- use phentolamine, SVT, VT, HTN, ARF

27
Q

T/F Atropine crosses the BBB?

A

True

28
Q

What causes paradoxical bradycardia after Atropine use?

A

Low-dose atropine causes bradycardia either by acting on the sinoatrial node or by its effects on central muscarinic receptors increasing vagal activity