Adenovirus Flashcards Preview

Medical microbiology > Adenovirus > Flashcards

Flashcards in Adenovirus Deck (14)
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1
Q

Adenovirus type involvec in adults

A

4, 8. 19

2
Q

Adenovirus tpe involved in first years of life

A

1.2.5

3
Q

Adenovirus type involved in school children

A

3 and 7

4
Q

T or F: incidence of adenovirus infxn is higher in patients undergoing bone transplant

A

True

5
Q

Non-enveloped icosahedral linear dsDNA
Replication in nucleus
Pentoprotein (detachment of cells from monolayer)
Inhibits host macromolecular synth and mRNA transport to cytoplasm

A

Adenovirus

6
Q

Target cells of adenoviruses

A

Epithelial cell linings of the lung and Other enteric organs

7
Q

Adenovirus entry

A

Receptor mediated endocytosis

  • *penton protein base with alpha v protein
  • *serotype specific clinical manifestation depend on difff on fibers and penton proteins
8
Q

Causes hemmorhagic cystitis

A

Group B serotype

9
Q

Causes RTIs

A

Group C serotype

10
Q

Causes epidemic keratoconjunctivitis

A

Group D

11
Q

Coxsackie-adenovirus receptor

A

ACDEF

12
Q

What sample is collected for virus isolation? And when is it collected?

A

Urine, feces, leukocytes, throat swab, eye swab CSF

During onset of clinical symptoms

13
Q

Gold standard Diagnosis which forms monolayers in test tube and inoculation of samples

A

Cell culture

**positive: CPE

14
Q

T or F: adenovirus elicits both humoral and CMI

A

Tru

*humoral: neutralizing abs target hexon