Adrenal Cortical Tumors Flashcards Preview

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Flashcards in Adrenal Cortical Tumors Deck (6)
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1
Q

What percentage of cortical neoplasms are hormonally active in kids?

A

95% (50% in adults)

2
Q

What is the most common benign cause of Cushing in children?

A

McCune-Albright syndrome (fibrous bone dysphasia, cafe au lait spots, and precocious puberty) - bilaterally macronodular adrenalcortical disease producing cortisol.

3
Q

What is the most common cause of Cushings in children less than 6?

A

ACC - 60-80 % of all cases of Cushing

4
Q

DDx for Cushing in children?

A
ACC
McCune-Albright 
Pituitary adenoma 
Nodular adrenal hyperplasia 
Primary pigmented nodular adrenocortical disease
5
Q

Symptoms os sex hormone producing tumors?

A

Virilizing- most common presentation of cortical tumors in kids.

  • Boys: precocious puberty
  • Girls: clitoral hypertrophy, hirsutism and Acne.

Feminizing- rare estrogen producing tumors.

Girls: precocious isosexual development
Boys: gynocomastia, accelerated growth, delayed puberty.

6
Q

Primary vs. secondary causes of hyperaldosterone?

A

Primary: Aldosterone secreting tumor or bilateral adrenal hyperplasia (more common)

Secondary: renin overproduction - cirrhosis, CHF, renovascular disease or renin producing renal tumor.