Adrenal Pathology Flashcards Preview

Endo/Repro Wk 1 > Adrenal Pathology > Flashcards

Flashcards in Adrenal Pathology Deck (18)
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1
Q

Cushing syndrome

A

excess steroid production

ie elevated free serum cortisol

2
Q

Dx of Cushing syndrome

A

24 hr free urine cortisol

b/c pulsatile in nature, higher in the morning

3
Q

When can you use a dexamethaxone suppression test

A

in Cushing disease

ie pituitary tumor secreting ACTH

4
Q

Iatrogenic Cushings labs
cortisol
ACTH

A

high cortisol

low ACTH

5
Q

What happens when you don’t taper steroids?

A

iatrogenic Addison’s disease

  • adrenal medulla begins to atrophy
  • need to taper so it can grow more and become more functional before quitting steroids
6
Q

Pituitary Cushings labs
cortisol
ACTH

A

high cortisol
high ACTH
*responds to dexamethaxone suppression test

7
Q

Adrenal Cushings labs
cortisol
ACTH

A

high cortisol
low ACTH
*b/c feedback inhibition is working

8
Q

Paraneoplastic Cushings labs
cortisol
ACTH

A

high cortisol

high “fake” ACTH, ie ACHTrp

9
Q

Function of aldosterone

A

retain salt and water

excrete K+

10
Q

2˚hyperaldosteronism

renin and aldosterone levels

A

high renin
high aldosterone
*due to decreased renal blood flow, renin-producing tumor

11
Q

Adrenocortical tumor
manifestation
prognosis

A

sudden viralization

necrotic, ugly tumor as abdominal mass

12
Q

Congenital adrenal hyperplasia

basics

A

21-hydroxylase deficiency is more common
basically can’t make mineral and/or glucocorticoids, so shunted to sex hormones
3 forms: servere, moderate, late-onset

13
Q

Addison’s disease

basics

A

1˚ chornic adrenal insufficiency

  • hypotension
  • skin hyperpigmentation
  • weakness, fatigue, GI complaints
14
Q

1˚ acute adrenal insufficiency

etiologies

A

Addisonian crisis
rapid steroid withdrawl (adrenals atrophy–need to taper)
massive adrenal hemorrhage

15
Q

Waterhouse-Friedrichsen Syndrome
etiology
complications

A

N. meningitidis infection
DIC –> massive adrenal hemorrhage
==> Addisonian crisis

16
Q

2˚adrenal insufficiency

etiologies

A

pituitary or hypothalamic insufficiency
tumors, infections, etc
overal decrease in cortisol
mineralcoriticoids normal, no hyperpigmentation

17
Q

Pheochromocytoma
basics
manifestations
path

A

tumor making catecholamines
paroxysmal crises
path: salt and pepper nuclei, Zellballen

18
Q

Neuroblastoma
basics
population

A

neural crest derivation

common in children