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Flashcards in Adverse drug reactions Deck (11)
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1
Q

What is an adverse drug reaction?

A

Noxious and unintended response to drug

At a dosage used in prophylaxis, diagnosis or treatment

2
Q

What are the 3 types of time delay for the onset of an ADR?

Adverse drug reaction

A

Acute

Sub-acute

Latent

3
Q

What are the characteristics and common reactions of each type of onset time delay?

A

Acute

  • within 60 minutes
  • bronchoconstriction

Sub-acute

  • between an hour and a day
  • Rash or serum-sickness

Latent

  • over 2 days
  • Eczematous eruption
4
Q

How is the severity of an ADR classified?

A

Mild
Moderate
Severe

5
Q

What are the classes of ADR’s?

Type A-F

A
A - Augmented
B - Bizarre
C - Chronic 
D - Delayed 
E - End of treatment 
F - Failure of treatment
6
Q

What are potential causes of ADR’s?

A

Multiple drug therapies affecting each other

Inter-current disease

Race/Genetic polymorphisms

Age

Sex

7
Q

What is the main cause of a type A ADR?

A

Too high a dosage

8
Q

Pharmacokinetics refers to the _____ of a drug

A

Movement (within the body)

9
Q

What is pharmacogenetics concerned with?

A

Differences in how drugs are metabolised due to genetic differences between people

10
Q

Pharmacodynamics is the…

A

Mechanisms of action, and effects of a drug

11
Q

What is an idiosyncratic response to a drug?

A

Inherent abnormal response

Due to genetic abnormality