Alcohols effect on the body systems Flashcards
What does a deficiency of thiamine lead to?
Wernicke-korsakoff’s syndrome
What are the symptoms of wernicke-korsakoff’s syndrome?
Ataxia Nystagmus Ophthalmoplegia Confusion Confabulation
Where in the lungs is apsiration pneumonia most likely to occur?
Inferior right lobe of the lungs
Why does alcohol consumption cause tachycardia?
Alcohol has a negative inotropic effect
Wh/at are the cardiac symptoms of chronic alcohol use?
Tachycardia
Dilated cardiomyopathy
Wet beriberi
What is the pathogenesis of fatty liver disease?
Increased peripheral free fatty acids are delivered to the liver. NAD converted by alcohol to NADH which stimualtes lipid synthesis
There is decreased transport of fat out of hepatocytes due to intracellular tubulin impairement
What are the symptoms of alcoholic steatohepatitis?
Fever
Liver tenderness
Jaundice
What is the microscopic findings of alcoholic hepatitis?
Cellular steatosis
Mallory’s hyaline
What is the pathogenesis of cirrhosis?
Fibrosis deposited by interstitial cells of ito entraps hepatocytes causing a build up of toxic material
What are the external manifestations of portal hypertension?
Varices, splenomegaly, haemorrhoids, spider naevi and caput medusa
How does alcohol consumption cause acute pancreatitis?
Mechanism unknown, alcohol is directly toxic to pancreatic acinar cells or ductal epithelial cells
Alcohol prematurely activates digestive enzymes such as lipase that stimulates an inflammatory cascade and conseuent tissue fat necrosis. This is saponification
How does alcohol misuse cause chronic pancreatitits?
Secreteion of proteinaceous material into pancreatic ducfts with aa degree of eventual obstruction
What are the macroscopic findings of chronic pancreatitis?
Obvious scarring and sclerosis
Pseudocyst formation with fat necoris s
