Allman - General Principles Flashcards Preview

POD Exam 2 > Allman - General Principles > Flashcards

Flashcards in Allman - General Principles Deck (17):
1

Trimethoprim + Sulfamethoxazole

Bactrim; sequential inhibition of folic acid synthesis; SYNERGISM

2

Postantibiotic Effect

Persistent effect of an antimicrobial on bacterial growth following brief exposure of organisms to a drug

Aminoglycosides and Fluoroquinolones

3

Concentration Dependent Killing

Dependent on peak concentration; Greater than 10x MIC;

Aminoglycosides and Fluoroquinlones

4

Time Dependent Killing

Dependent on the amount of time the concentrations stay above the MIC during the dosing interval

B-lactams (Penicillins, Cephalosporins)

5

Antimicrobial agents that inhibit cell wall synthesis (7)

Penicillins
Cephalosporins
Carbapenems
Aztreonam

Vancomycin

Bacitracin
Cycloserine

6

Antimicrobial agents that inhibit protein synthesis/structure (8)

Aminoglycosides

Chloramphenicol

Erythromycin
Clindamycin
Lincomycin

Tetracycline

Streptogramins
Linezolid

7

Antimicrobial agents that interfere with cell membrane function (3)

Polymixin B
Colistin

Fungal Section

8

Antimicrobial agents that interfere with DNA/RNA Synthesis (2)

Rifampin
Fluoroquinolones

9

Antimicrobial agents that inhibit metabolism (4)

Isoniazid
Ethambutol

Sulfonamides
Trimethoprim

10

Cockroft-Gault Equation

Measures Renal Function: Creatinine Clearance (ml/min)

(140-Age) x Weight (kg) / (SrCr x 72)

Female - multiply by 0.85

11

Gram Positive Organisms (3)

Staphlococcus
Streptococcus
Enterococcus

12

Gram Negative Organisms - PIDDLY (7)
Ella Brothers

Haemophilus (H.flu)
Moraxella (M.Cat)
Salmonella
Shigella
Morganella
Neisseria*
Providencia*

*closer to FENCE bugs now

13

Gram Negative Organisms - FENCE (3)
PEK

Proteus
Escheria Coli
Klebsiella

14

Gram Negative Organisms - SPACE (5)
Bacters

Serratia
Pseudomonas
Acinetobacter
Citrobacter
Eneterobacter

15

Atypicals (3)
CML

Chlamydia (STDs)
Mycoplasma (walking pneumonia)
Legionella (water born)

16

Anaerobes (3)
PBC

Peptostreptococcus (mouth)
Bacteroides (GUT)
Clostridium (C Diff - colonic wall)

17

Box and One Coverage (SPACE bugs) - Goal = SYNERGY with 2 different mechanisms

Choose 1:
PCN: Piperacillin or Ticarcillin
Cephalosporin: Ceftazidime or Cefepime
Carbapenems: Imipenem or Meropenem (Doripenem)
Monobactam: Aztreonam (Ace in the Hole)

Add ONE:
Aminoglycosides: Gentamycin, Tobramycin, Amikacin
OR
FQN: Ciprofloxacin or Levofloxacin