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Flashcards in alzheimers Deck (12)
1

common causes of dementia?

alzheimers
vascular dementia
lewy body dementia

2

common frontotemporal dementia?

picks

3

function of apoprotein E4?

encodes a cholesterol transport protein

4

in alzheimers, you get widespread cerebral atrophy, affecting mainly?

hippocampus and cortex

5

microscopically, the deposition of plaques and neurofibrillary tangles due to?

played are due to A beta amyloid protein and neurofibrillary tangles are abnormal aggregations of tau proteins

6

in AD, tau proteins are excessively?

phosphoylated

7

what are neurofibrillary tangles?

paired helical filaments are partly made from a protein called tau

8

the three acetylcholinesterase inhibitors used in AD?

donepizil, galantamine and rivastagmine

9

moderate Alzheimer's who are intolerant of, or have a contraindication to, acetylcholinesterase inhibitors. what are they given?

memantidine

10

what drug class is mimentidine?

a NMDA receptor antagonist

11

how do you differentiate lewey body dementia from others?

Symptoms fluctuate
Association with parkinsonism (Lewey bodies found in parkinson as well)
causes visual hallucinations (often unpleasant and persecutory)

12

which drug can help improve symptoms in lewey body dementia?

rivastigmine