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Enamel, Dentine and Pulp > Amelogenesis > Flashcards

Flashcards in Amelogenesis Deck (13)
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1

what are the 4 stages of amelogenesis

pre-secretory
secretory
transition to maturation
post-maturation

2

what happens in the pre-secretory phase

the IEE cells differentiate to become tall columnar pre-ameloblasts

3

what does the pre-ameloblasts cell look like

nucleus away from the basal lamina

4

what happens in the secretory phase

pre-ameloblasts develop into ameloblasts with fully developed Tomes Processes on their secretory end.
deposition of the organic enamel proteins tuftelin/ amelogenin and inorganic components of enamel follow. Formation of HAP crystals and prism formation.

5

what is the role of the Tomes Processes on the ameloblast cells

packed with secretory vesicles which deposit the inorganic AND organic portions of enamel. formation of HAP prisms.

6

what happens to the ameloblast cell in the later stages of secretory phase

when all the enamel has been secreted, the cell becomes wider and the nucleus moves back down

7

what happens in the transition to maturation phase

the full thickness of enamel is achieved therefore enamel production STOPS.
50% cell death, cells lose tomes processes

8

what happens to the ameleoblast cell in the transition to maturation phase

cells shrink in size, lose tomes processes, and have a wider base

9

what happens in the post-maturation phase

the ameleoblasts shrink to form a protective layer for enamel

10

what is the difference in % of protein in mature and immature enamel

in mature 1% organic/protein
in immature, early forming enamel 30% (both non-ameleogenin and amelogenin proteins)

11

which cells diffrentiate to become pre-ameloblasts

the IEE cells of the growing enamel organ

12

what is meant by 'polarised cell'

when the nucelus moves away from the basal lamina
in ameloblasts this means nucleus moves UP
in odonotobasts this means nucleus moves DOWN

13

what is meant by 'polarised cell'

when the nucelus moves away from the basal lamina
in ameloblasts this means nucleus moves UP
in odonotobasts this means nucleus moves DOWN