AML Flashcards

1
Q

Myeloid lineage cells

A

Granulocyte, monocytes, erythroid, or megakaryotes

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2
Q

WHO AML Classifications

A

AML with recurrent genetic abnormalities

AML with myelodysplasia-related features

Therapy-related AML and MDS

AML, not otherwise specified

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3
Q

Complications of AML blasts

A

Anemia, bleeding increased risk of infection

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4
Q

Incidence of AML in children.

A

Less than 10 percent of acute leukaemias in children less than 10

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5
Q

How is AML diagnosed

A

By bone marrow biopsy using morphological, cytochemical, immunophenotypic, and cytogenics slash molecular analysis.

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6
Q

In order to diagnose AML what percentage of the total cellularity in bone marrow must the blast forms account for

A

20% and must be identified as myeloid lineage

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7
Q

What are erythematous to violaceous, tender nodules and plaques suggestive of acute neutrophil if dermatosis called

A

Sweet syndrome

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8
Q

What are s/s of leukaemic involvement of the oropharynx?

A

Gingival hypertrophy, esp AML monocytic subtypes

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9
Q

Name 4 electrolyte abnormalities in tumour lysis syndrome

A

Hyperphosphotemia, hypocalcemia, hyperuricemia, hyperkalemia

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