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Flashcards in Androgen Pharm Deck (14)
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1
Q

Peptide hormones
Hypothalamus releases

AP releases (3)
Synctiotrophoblast releases
Placenta releases
Developing testes releases M____ (3)

A

GnRH

FSH, LH, Prolactin

HcG

Placental lactogen

mullerian inhibitory factor
MIH, MIS, AMH

2
Q

AMH/MIF leads to

Testes convert __ to ___

Testosterone needed for __

DHT needed for

Unilateral Mullerian duct regression leads to loss of ___/___, seen in ___

Wolfian duct regression bilateral leads to loss of ___/___, important for __

differentiation occurs around ___ wks

A

Mullerian duct regression

T to DHT

Wolffian/Ejac ducts

virilization of external genitalia

cloaca/Mullerian duct, males

cloaca/ Wollfian duct, females

8

3
Q

FSH and LH act on __ and __ respectively

these inc ___ production, eventually forming __ via 5a reductase

Gonadal dysgenesis: appropriate sex differentiation requires coordinated actions of ___ and ___ and the conversion of __ to ___

Lack of MIH leads to __
With DHT pt is ___, lacking T leads to ____

+MIH, patient is __
with DHT is ___, without T is ___

A

sertoli/Leydig

Testosterone, DHT

MIH, Testosterone, T to DHT

Internal female
External male, external female

Internal male
External male
External female

4
Q

5A reductase
Type 1 found in
KO Leads to ___ estrogen toxicity
eventually, __ demise and ___ defects

Type 2 found in ___
defic results in ___ at birth, usually ___

can be reversed at puberty as __ is converted by ____ resulting in male gender

A

Liver/skin
midgestation
fetal, parturition

urogenital tract/liver
ambiguous gender ID, female

T, type 1 5AR

5
Q
Sex hormones
Steroids
E includes
P includes
Androgens include

Kd for Andogen receptors DHT ___< T

GnRH pulse generator drives ____ of FSH/LH

Gonadal steroidogenesis begins w ___

A

Estrone/Estradiol/Estriol
Progesterone, MPA
T, DHT

1000

pulsatile secretion

cholesterol

6
Q

Androgen actions mediate ___
S
L
Possible M and A

as an anabolic steroid, inc in ____ and stimulates ____

Actions in sexually mature adult is ___

AR is ___ in normal males, anabolic actions require ___ suggesting cross talk w ___ or other receptors

A

male SSC
spermatogenesis
libido
male pattern behavior, adipocity

lean body ass, erythropoeisis

fxnally saturated, very high doses, GR

7
Q

Inhibitors of androgen action is effective in tx of
H/C of prostate (__ dep)
A (__ dependent)
M (__ and __ dependent)

V (such as __ and __)
P (__ dependent)
Decrease ___ in sex offenders (__ dependent)

Testosterone binds __ or activated by ___ to DHT, which binds ___

___ occurs, affecting __ of T dependent genes

A

hyperplasia/carcinoma, DHT
Acne, T
male pattern baldness, T/DHT

Virilization in females, hirsutism/clitormegaly
PP in boys, T
sex drive, T

AR, 5AR, AR

Homodimerization, cell trxn

8
Q

T criculates in the blood bound to __ or ___

only __ T diffuses through PM of cells

androgenic activity is much greater for ____

__ inhibits 5AR, can be used for ___ and ___

actions of steroid determined by ___ and ___

A

SHBG, albumin

free

DHT

finasteride, BPH, male pattern baldness

levels and bioavailability

9
Q

__ in structure of AR alter physio responses to __ and __

CAG island between 12-32 Gln is ___
above 40, leads to ___

Repeats more common in A than H than C than A

Greater number repeats, ___ effective the receptor

Mutations can result in __ or ___ to T/DHT

A

Polymorphisms, T/DHT

normal
spinal/bulbar muscle atrophy

Asians, Hispanics, Caucasians, Africans

less

partial/complete insensitivity

10
Q

__ provides negative feedback to hypothalamus on GnRH

Leuprolide is a ____ agonist

stimulates short term secretion of __ and ___
continued exposure disrupts ___ of GnRH, inhibiting ___ sec

Indications 
P
P
U
E
can also treat
B
B
P
A

T

GnRH

LH/FSH, pulsatility, FSH/LH

Prostate cancer
PP
uterine leiomyoma
endometriosis

BPH
BC
prementrual syndrome

11
Q

Ketoconzaole/Liarozole injibits steroidogenic p450s ___ and ____

Keto is an ___ antifungal
can disrupt synthesis of ___ and __ and ___

Differential inhibition leads to more selective inhibiton of ___

Indicated for ___

A

CSCC, 17A hydroxylase/lyase

imidazole, Aldo/cort/Testosterone

Prostate cancer

12
Q

Finasteride

____ analog of T that acts as a ___, ___ inhibitor of ___ in the prostate, S___, E__, h____

Indicated for P/B/A

leads to reduction in __ but normal levels of ___

Flutamide/Cyproterone acetate/Spironolactone block NF to ____ and inc serum ___ by inc _____

act by inhibiting ___ in Hypo and DNA

As T levels rise, inhibitor effectiveness is ___

To decrease T/DHT action, combo therapy w __ or ___ can maximize effects

A

synthetic 4aza
competitive, selective, T25AR, seminal vesicles, epididymis, hair follicles

Prostate cancer, BPH, alopecia

DHT, T

HPA, LH, pulse freq

AR

compromised

GnRH, leuprolide

13
Q

Flutamide

___ anti-androgen used as anti-hormone in tx of ____

most effective when combined w ___

Indicated for ___ and ___

virilization is a fxn of ___

can occur w ___ or low ___

Androgen replacement therapy can be useful for __ and ___

A

Nonsteroidal, Metastatic prostatic carcinoma

GnRH agonist, leuprolide

prostate cancer, BPH

relative steroid levels

high T, E2

osteoporosis, sex dysfxn (libido)

14
Q

Testosterone is a schedule C3 controlled substance delivered as ___

names A and T

Indicated for ___ or ___ in men
such as ___
__ in postmenopausal women

can tx ___ assc w RF, AIDS assc ___, and ___ to ___ gender change

A

topical skin gel

Androgel, Testim

Congenital, acquired hypogonadism
delayed puberty
BC

Anemia, wasting syndrome, female to male