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Flashcards in anemia Deck (24)
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1
Q

Define WAHA

A

warm autoimmune hemolytic anemia

2
Q

WAHA pearls

A

IgG
Spleen
Spherocytes

3
Q

Define CAHA

A

cold autoimmunei hemolytic anemia

4
Q

CAHA pearls

A

IgM, complement
Intravascular hemolysis
Agglutination

5
Q

Clinical Signs of CAHA

A

Chronic hemolysis aggravated by cold

Pallor/cyanosis in cold body parts

6
Q

What are Hemoglobinopathies?

A

Structurally abnormal hemoglobin - most important one is sickle cell anemis

7
Q

Describe sickle beta chains

A

valine where a glutamate should be

8
Q

Treatment of sickle crisis

A

Blood transfusion, BMT

9
Q

Problems in Beta-thalassemia

A

defective transcription, translation, or mRNA processing of beta-chain

10
Q

Thalassemia can look like this disorder

A

iron def. anemia

hypochromic, microcytic amnemia

11
Q

Heinz body anemia refers to this

A

G6PD def.

12
Q

Cause of Microangiopathic Hemolytic Anemis

A

Physical trauma to cells

13
Q

Hallmark of Microangiopathic hemolytic anemia

A

triangulocyte

14
Q

ACOD pearls

A

Infections, Inflammation, Malignancy
Iron metabolism disturbed
Mormochromic, normocytic
Usually mild

15
Q

Anemia of Renal Disease Pearls

A

End stage renal failure
Lack of EPO
Echinocytes

16
Q

Anemia of Liver Disease Pearls

A

Multiple causes, usually complicated

Acanthocytes

17
Q

Aplastic Anemia disease Pearls

A

Pancytopenia
Empty marrow
Most are idiopathic

18
Q

None idipathic causes of Aplastic anemia

A

Drugs
Viruses
Pregnancy
Fanconi anemia

19
Q

For what anemias may you see spheroctyes?

A

WAHA, CAHA

20
Q

Name the abnormal shape anemias

A
G6PD
Microangiopathic Hemolytic Anemia
Thallasemia
Hemoglobinoptahies
Anemia of Renal Disease
Anemia of LIver Disease
21
Q

List some cause for Normocytic, normal shape RBC anemia

A

AOCD
Aplastic Anemia
Anemia of blood loss

22
Q

How would you treat WAHA?

A

Steroids and splenectomy

23
Q

Definitive diagnostic tool for distinguishing Hemoglobinapthies and Thallasemia

A

Hemoglobin Electrophoresis

24
Q

Some aplastic anemia

A

Blood
G-CSF, Prednisone, AGD (immunosupprant)
Last resort - BMT