Dominance (predominant tone)
Arterioles and veins
Sympathetic (adrenergic)
Dominance (predominant tone)
Heart
Parasympathetic
Dominance (predominant tone)
Radial muscle of the iris
Sympathetic alpha adrenergic
Dominance (predominant tone)
Sphincter and ciliary muscle of the eye
Parasympathetic
Dominance (predominant tone)Bronchial smooth muscle
Parasympathetic
Dominance (predominant tone)
GIT and urinary tract
Parasympathetic
Dominance (predominant tone)
Salivary glands
Parasympathetic
Dominance (predominant tone)
Sweat glands
sympathetic (cholinergic) - exocrine
alpha-adrenergic apocrine
Alpha 1 tissue affect and action
vascular smooth muscle - contraction
pupillary dilator - radial muscle contraction
Heart- contraction
Urinary sphincter contraction
Alpha 2 tissue affect and action
- adrenergic/cholinergic nerve terminals - inhibition of transmitter release
- vascular smooth muscle: contraction
Vasoconstriction
inhibits adenylyl cyclase to decrease cAMP
Beta 1 tissue affect and action
increased Heart rate, juxtaglomerular cells increased contraction; increases renin release
Beta 2 tissue affect and action
Vascular smooth muscle - relaxation
Skeletal muscle - promotes Potassium uptake
stimulate adenyly cyclase, and increase cAMP
Beta 3 tissue affect and action
Fat cells- activates lipolysis
Adrenergic neurotransmitter
Norepinephrine
Cholinergic neurotransmitter
Epinephrine
Receptor type for alpha and beta
Metabotropic
Receptor types for nicotinic
ionotropic
Receptor types for muscarinic
metabotropic
Ionotropic receptor
ligand gated ion channels
Metabotropic receptor
not ion channels, they are complexed to intracellular cascades, G protein
Agonistic activity
- drug acts as precursor
- drug stimulates release of NT
- Drug stimulates postsynaptic receptors
- Drug blocks autoreceptors, increases NT
- Drug blocks reuptake
- Drug inactivates AChE
Antagonistic activity
- Drug inactivates synthetic enzyme, inhibits synthesis NT
- Drug prevents storage of NT in vesicles
- Drug inhibits release of NT
- Drug stimulates autoreceptors, inhibits synthesis/release NT
- Drug blocks postsynaptic receptor
M1, M3, and M5 tissue affect and action
smooth muscle contraction (bronchoconstriction
Vasodilation
Activate phospholipase C
M2 and M4 tissue affect and action
Decrease HR and decreased contractility.
Inhibit adenylate cyclase