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Flashcards in anti-arrhythmics Deck (33)
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1
Q

quinidine - class

A

class IA anti-arrythmic

2
Q

procainamide - class

A

class IA anti-arrythmic

3
Q

disopyramide - class

A

class IA anti-arrythmic

4
Q

Which class of drugs treats Wolf-Parkinson-White?

A

class IA anti-arrythmic

5
Q

side effect of all class IA anti-arrythmics?

A

arrhythmias (include torsades de pointes)

6
Q

which anti-arrhythmic is associated with vertigo, headache, tinnitus and psychosis (and what is that called?)?

A

quinidine (cinchonism)

7
Q

which anti-arrhythmic can cause drug induced lupus (as well as psychosis)?

A

procainamide

8
Q

which anti-arrhythmic can cause urinary retention, double vision, and constipation?

A

disopyramide

9
Q

how do class IA anti-arrythmics act?

A

bind to activated sodium channels –> prolonged phase 0 depolarization (phase 3 repolarization is also delayed)

10
Q

how do class IB anti-arrythmics act?

A

bind to both activated and inactivated sodium channels

11
Q

lidocaine - class

A

class IB anti-arrythmic

12
Q

tocainide - class

A

class IB anti-arrythmic

13
Q

mexiletine - class

A

class IB anti-arrythmic

14
Q

side effect of all class IB anti-arrythmics?

A

arrythmias

15
Q

flecainide - class

A

class IC anti-arrythmic

16
Q

encainide - class

A

class IC anti-arrythmic

17
Q

propafenone - class

A

class IC anti-arrythmic

18
Q

patients with ______ should not be treated with class IC anti-arrythmics?

A

structurally abnormal heart (ex: post MI)

19
Q

sotalol - class

A

class III anti-arrhythmic (with potent beta blocking activity)

20
Q

ibutilide - class

A

class III anti-arrhythmic

21
Q

dofetilide - class

A

class III anti-arrhythmic

22
Q

amiodarone - class

A

class III anti-arrhythmic

23
Q

bretylium - class

A

class III anti-arrhythmic

24
Q

how do class III anti-arrhythmics work?

A

bind potassium channels –> prolonged phase 3 repolarization

25
Q

side effects for amiodarone

A

pulmonary fibrosis, hepatotoxicity, thyroid dysfunction, cardiac arrhythmias, ataxia, photosensitivity

26
Q

mechanism of amiodarone

A

classified as class III but has class I-IV activity

27
Q

verapamil - class

A

class IV anti-arrhythmic

28
Q

diltiazem - class

A

class IV anti-arrhythmic

29
Q

class IV anti-arrhythmic mechanism

A

block calcium channels. blocking of calcium in SA and AV nodes –> slows phase 4 spontaneous depolarization (prolonged PR interval). also delays repolarization of myocytes

30
Q

what can be used to suppress ectopic pacemakers especially when associated with digoxin toxicity?

A

potassium

31
Q

what can be used to treat torsades de points as well as digoxin toxicity?

A

magnesium

32
Q

moricizine - class

A

class IC anti-arrhythmic

33
Q

drugs that can’t be used in people with long QT syndrome (8)

A

quinidine, procainamide, sotalol, amiodarone, disopyramide, dofetilide, phenothizines and tricyclic antidepressants