Anti Coag Drugs Flashcards
Name the 8 antiplatelet drugs we learned
Aspirin Clopidogrel Ticlopidine Prasugrel Dipyridamole Abcixamab Eptifibabtide Tirofiban
Which drugs are ADP receptor antagonist
Clopidogrel, Ticlopidine, Prasugrel
Abciximab, Eptifibatide, and Tirofiban all work via this mechanism
GPIIb/IIIa receptor inhibitor
Heparin potentiates this
Antithrombin III to inactivate Xa and IIA leads to no clotting
Direct Thrombins work via this mechanism
bind to thrombin and inhibit enzyme
Antidote for heparin?
Protamine - binds to neg. charged heparin and prevents its action
Describe the 3 types of indirect thrombin anti-coagualtion drugs
Unfractionated heparin - inactivate Xa and IIa
Low molecular weight heparin - inactivate Xa and some IIa
Fondaparinux - inactivate Xa - not reversed by protamine
Most common oral anticoagulation drug
Warfarin
Purpose of tPA drugs
activate plasminogen and dissolves thrombi
name the 4 direct thrombin drugs
Lepirudin
Bivalirudin
Argatroban
Dabigatran etexilate
How does Warfarin work?
Blocks synthesis of vitamin K dependent clotting factors
Antidote for warfarin?
Vitamin K (Phytonadione)
Describe the process of plasminogen and clot breakdown
plasminogen —> plasmin, plasmin breaks clot down to FDP
Describe a pharmacodynamic effect between warfarin and the body
effect of drug on body
decrease platelet/clotting factors
decrease availability of vit. K
ADME describes the effects of the body on drugs also called this?
Pharmacokinetics
