Anti-Neoplastics

Question 1

DHFR inhibitor
prevents nucleotide synthesis
cell cycle specific (S phase)

Answer 1

Methotrexate

Question 2

prevents nucleotide synthesis by inhibiting pyrimidine synthesis
cell cycle specific (S phase)

Answer 2

5-fluorouracil

Question 3

prevents DNA synthesis by inhibiting DNA polymerase
in pyrimidines (CTP)
cell cycle specific (S phase)

Answer 3

Cytarabine (Ara-C)

Question 4

prevents DNA synthesis by inhibiting DNA polymerase
in purines (ATP)
cell cycle specific (S phase)

Answer 4

Fludarabine

Question 5

damage DNA by crosslinking via alkylation

cell cycle non specific

Answer 5

cyclophosphamide
ifosfamide
busulfan
melphalan

Question 6

cross-links and destroys DNA

cell cycle non specific

Answer 6

cisplatin

Question 7

Generate free radicals. Intercalates in DNA.

cell cycle non specific

Answer 7

Doxorubicin

Question 8

Strand breaks via inhibition of topoisomerase II

cell cycle specific (S/G2)

Answer 8

Etoposide

Question 9

Hyperstabilize microtubules in M phase preventing anaphase.

Cell cycle specific (M phase)

Answer 9

Paclitaxel

Question 10

protects bladder from acrolein damage caused by cyclophosphomide and ifosfamide

Answer 10

Mesna

Question 11

treats high levels of methotrexate in the blood from renal failure

Answer 11

glucarpidase

Question 12

“saves” healthy cells by giving them folate that can’t be used by cancer cells

Answer 12

leukovorin