Anti Rheumatoid Drugs

Question 1

• folate metabolism inhibitor (T & B cell)

- non-biological

Answer 1

Methotrexate

Question 2

• inhibits macrophages, maybe TLR9 in dendritic cells

- non-biological

Answer 2

Hydroxychloroquine

Question 3

• Pyrimidine synthesis inhibitor in T cells

- non-biological

Answer 3

Leflunomide

Question 4

• Inhibits COX & scavenges free radicals (antigen presenting cells & T cells)
• non-biological

Answer 4

Sulfsalazine

Question 5

• reduces macrophage phagocytosis and affects antigen presenting cells & T cells
• non-biological

Answer 5

Gold

Question 6

• Blocks DNA synthesis, primary site of action T cell

- non-biological

Answer 6

Azathioprine

Question 7

• Calcineurin inhibitor to inhibit T cell activation (via IL-2 synthesis inhibition)
• non-biological

Answer 7

Cyclosporine

Question 8

• Block TNF action

- biological DMARD

Answer 8

Etanercept, Inflixumab

Question 9

• Interleukin 1 receptor antagonist

- biological DMARD

Answer 9

Anakinra

Question 10

• Blocks T cell activation by antigen presenting cell (CD 80)
• biological DMARD

Answer 10

Abatacept

Question 11

• Blocks B cell activation (CD20)

- biological DMARD

Answer 11

Ritixumab