Anti thrombosis and anti platelet drugs Flashcards

1
Q

What is atherosclerosis?

A

Damage to the endothelium and recruitment of foamy macrophages rrich in cholesterol which then results in plaque formation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What happens when the plaque ruptures in atherosclerosis?

A

Platelet recruitment and activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the target in preventing arterial thrombus?

A

Platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How does aspirin work?

A

Inhibits Cyclo oxygenase which is necessary to produce thromboxane A2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does cycloxoygenase do?

A

Necessary to produce thromboxane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the side effects of aspirin?

A
  1. Bleeding
  2. Blocks production of prostoglandins
  3. GI ulceration
  4. Bronchospasm
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What kind of drug is Clopidogrel?

A

ADP receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

In what condition is aspirin contraindicated?

A

Asthmas (Aspirin causes bronchospasm)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What kind of drug s dipyridamole?

A

Phosphodiesterase inhibitor which reduces production of cAMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How long do you have to stop antiplatelet agents for before an operation?

A

7 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly