Antibodies--Diebel Flashcards Preview

IHO Wk 2 > Antibodies--Diebel > Flashcards

Flashcards in Antibodies--Diebel Deck (26)
Loading flashcards...
1
Q

Which Ig is found in its secreted, pentameric form?

A

IgM

2
Q

Which Ig is found in its secreted, dimer form?

A

IgA

3
Q

What is the J-chain?

A

protein segment that holds IgM and IgA in their respective multimeric forms

4
Q

What are the two subtypes of light chains?

A

lambda and kappa

5
Q

T/F one antibody can have both a lambda and a kappa light chain

A

F

one antibody has either identical lambdas or identical kappas

6
Q

Valence of IgG

A

2

7
Q

Valence of IgA

A

4

8
Q

Valence of IgM

A

5 (tricky, should theoretically be 10)

9
Q

Which IgG binds complement best?

A

IgG3

10
Q

Best Ig for fixing complement

A

IgM

11
Q

Best Ig for toxin neutralization

A

IgG (also IgA)

12
Q

Best Ig for mast cell/basophil degranulation

A

IgE

13
Q

Best Ig for combined toxin neutralization and antiviral activity

A

IgA

14
Q

This Ig is present to fight of parasitic infections

A

IgE

15
Q

VDJ segments are found in what part of antibody?

A

heavy segment

16
Q

VJ segments are found in what part of antibody?

A

light segment (either lambda or kappa)

17
Q

What is the function of RAG recombinases?

A

recognize random signals and cut and paste new base pairs in

18
Q

What is the function of exonucleases in antibody recombination?

A

cut off some base pairs before ends of transcript are joined

19
Q

What is the function of terminal deoxynucleotidyltransferase?

A

add random base pairs

20
Q

What is the function of activation-induced cytodine deaminase?

A

converts random cytosines to uracils: guanine mismatch

21
Q

What is an isotype for antibodies?

A

different classes (ie IgG vs IgM)

22
Q

What is an allotype for antibodies?

A

allelic variation–one from mom and one from dad

23
Q

What is an idiotype for antibodies?

A

different specificities, ie one for a certain toxin

24
Q

C1q binds what area of antibodies?

A

two adjacent Fc regions

25
Q

Why is IgM better at activating complement than IgG?

A

IgM is found in its pentameric form, therefore 2 adjacent Fc regions are always next to one another. 2 adjacent Fc regions activate C1q, the first molecule in the complement cascade

26
Q

This very special CD is located on B-cells and helps them talk to CD4+ T-cells

A

CD40 (it binds CD40L, CD40 ligand on the CD4+ T-cell)