Anticancer Antibiotics Flashcards Preview

Oncology > Anticancer Antibiotics > Flashcards

Flashcards in Anticancer Antibiotics Deck (4)
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1
Q

Anthracyclines

A

Doxorubicin, Daunorubicin.
- Intercalate DNA, Binds cell membrane and generate ROS.
• Doxorubicin: Sarcomas, Breast, Liver, ALL, Lymphomas
• Daunorubicin: ALL, Myelocytic Leukemias
- AE: Irreversible dose-dependent Cardiotoxicity, transient Myelosuppression, severe alopecia, stomatitis

2
Q

Bleomycin

A
  • DNA-Bleomycin-Fe2+ complex + O2 -> ROS -> Scission of DNA.
  • Germline cancers, Lymphomas (but not curative)
  • AE: pulmonary fibrosis, mucocutaneous reactions, Alopecia, hyperpyrexia
3
Q

Mitomycin C

A
  • Function as alkylating agent to cross link DNA.
  • Bladder and rectal cancers
  • AE: Severe Myelosuppression, Pulmonary fibrosis, Hemolytic Uremic Syndrome
4
Q

Dactinomycin

A
  • Intercalate DNA to interfere with movement of RNA polymerase
  • Used in pediatric tumors. Wilms tumor (w/Vinblastine), Choriocarcinoma (w/MTX)
  • AE: Myelotoxicity, Stomatitis, Alopecia