Anticonvulsants Flashcards Preview

Neurology > Anticonvulsants > Flashcards

Flashcards in Anticonvulsants Deck (14)
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1
Q

What is a seizure?

A

High frequency bursts of APs (Influx of calcium and the activation of sodium channels…or the downregulation of inhibitory neurons)q

2
Q

What are the 3 MOAs of anticonvulsant drugs?

A
  • Block the voltage gated Na channel
  • Block the voltage gated Ca channel
  • Potentiate GABA action
3
Q

Blocking of the voltage gated Na channel does what?

A

Reduces the ability of the neurons to fire

4
Q

Common Adverse Effects of Anticonvulsants?

A

suicidal ideation 1-24 weeks after starting the drug

5
Q

GABA potentiators

A

Clonazepem (benzodiazepine)
Phenobarbital (barbituate)
Felbamate

CPF

6
Q

DOC for status epilepticus?

A

IV Lorazepem

7
Q

Calcium channel blockers

A
  • Ethosuxamide
  • Pregabalin
  • Gabapentin
8
Q

Phenytoin MOA

A

Na channel blocker,,,,remember that these drugs can only inhibitactive or inactive channels. NOT deactive

9
Q

Carbamezapine BBW

A

agranulocytosis

10
Q

Greatest risk of adverse outcomes in pregnancy>

A

Valproate

11
Q

Two drugs that potentially cause fetal hydantoin syndrome?

A

Phenobarbital and carbamezabine

12
Q

Hirsutism?

A

Phenytoin

13
Q

High risk for SJS of TEN

A

asians with HLA-B1502

14
Q

What are the two drugs that don’t produce SJS or TEN ever

A

Clonazepem and lacosamide