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pharma final > Antiemetics > Flashcards

Flashcards in Antiemetics Deck (15)
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1
Q

List the antiemetic drug classes used

7

A

5HT3 blockers

D2 blockers

H1 blockers

M1 blockers

NK1 blockers

Cannabinoids

Glucocorticoids

2
Q

List the 5HT3 blockers

A

Ondansetron

Granisetron

3
Q

List the D2 blocker anti emetics

A

Metoclopromide
Domiperidone

AND many of the antipsychotics, used at LOW doses. Antiemetic effects before AP effects

most common:
Prochlorperazine

Also:
Promethazine
Chlorpromazine

4
Q

H1 blocker antiemetics

A

Diphenhydramine
Dimenhydrinate

Promethazine
Meclinzine

5
Q

Antimuscarinic antiemetics

A

Scopolamine

Dimenhydrinate

6
Q

Cannabinoids

A

Dronabinol - THC

Nabilone - analog

7
Q

Which glucocorticoids are used as antiemetics

A

Dexamethasone

Methylprednisolone

8
Q

NK1 blockers

A

Aprepitatnt

Fosaprepitant

9
Q

What is the NK1 a receptor for

A

Substance P, aka Neurokinin

10
Q

Serious side effects of Ondansetron

A

Long QT syndrome and torsades

Serotonin syndrome, esp with SSRIs

11
Q

Metoclopromide SEs

A

Diarrhea
Extrapyramidal SEs, tremors, tardive dyskinesia

Long QT, torsades

Rhabdomyolysis

Neuroleptic malignant syndrome

Hyperprotlactinemia, galactorrhea, impotence

Sedation

12
Q

What is Neuroleptic malignant synd

A

Symptoms include high fever, confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate

13
Q

What is serotonin syndrome

A
High fever, 
Confusion, 
Hallucinations
Hypomania
Headache, 
Tachycardia
Nausea and Diarrhea

Muscle Twictching, fasciculations, tremor, and hyperreflexia.

14
Q

What are the drugs used to treat obesity

A

Anorexiants:

  • Phentermine
  • Diethylpropion

Both are monoamine releasers,
Inhibit NET/DAT, amphetamine like effects and potential for abuse

Lipase inhibitor
- Orlistat

15
Q

What are the prokinetic drugs
4 classes
6 drugs

A

D2 antagonists AND 5HT4 Agonists
-Metoclopromide and Domperidone

Muscarinics

  • Bethanachol
  • Neostigmine

5HT4 agonists, 5HT3 antagonists
Cisapride

Erythromycin

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