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Clinical Pharm > Antihypertensives > Flashcards

Antihypertensives Flashcards

1
Q

metoprolol (lopressor) MOA

A

B1 blocker

B2 with increased dose

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2
Q

Metoprolol (lopressor) bolus dose

A

2.5-5 mg q 2 minutes

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3
Q

Metoprolol (lopressor) considerations

A
  • Bronchoconstriction

- Heart block

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4
Q

Esmolol (brevibloc) MOA

A

B1 blocker

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5
Q

Esmolol (Brevibloc) infusion dose

A

1-15 mg/min

50-500 mcg/kg/min

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6
Q

Esmolol (brevibloc) bolus dose

A

10-20 mg

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7
Q

Esmolol (brevibloc) loading dose

A

500 mcg/kg over 1 minute

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8
Q

Esmolol (brevibloc) considerations

A

PONV

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9
Q

Labetalol (normodyne) MOA

A

a1 blocker

B1 & B2 blocker

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10
Q

Labetalol (normodyne) infusion dose range

A

0.25 - 1.0 mg/kg

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11
Q

Labetalol (normodyne) bolus dose

A

5-20 mg q 5-10 min

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12
Q

Labetalol (normodyne) considerations

A 
Beta:alpha = 7:1
Max = 300 mg
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13
Q

Nitroprusside (nipride) MOA

A

direct NO donor - arterial and venous

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14
Q

Nitroprusside (nipride) infusion dose range

A

0.1-0.5 mcg/kg/min

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15
Q

Nitroprusside (nipride) bolus dose

A

20-40 mcg

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16
Q

nitroprusside (Nipride) considerations

A

Cyanide

Max dose = 10 mcg/kg/min

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17
Q

Nitroglycerin (Nitrol) with MOA

A

Vasodilator, venous>arterial

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18
Q

Nitroglycerine (Nitrol) infusion dose range

A

5-200 mcg/min

0.1-1.5 Mcg/kg/min

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19
Q

Nitroglycerine (Nitrol) bolus dose

A

10-20 mcg

give 5-10 mcg/min

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20
Q

Nitroglycerin (Nitrol) considerations

A

Hypotension

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21
Q

Nicardipine (Cardene) MOA

A

Ca Channel blocker

Dihydropyridine

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22
Q

Nicardipine (Cardene) infusion dose range

A

5-25 mg/hr

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23
Q

Nicardipine (Cardene) bolus dose

A

None

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24
Q

Nicardipine (Cardene) considerations

A

Reflex tachycardia

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25
Q

Hydralazine (Apresoline) MOA

A

Vasodilator (arterial > venous)

26
Q

Hydralazine (apresoline) bolus dose

A

2.5-20 mg IV q 4 hours

27
Q

Hydralazine (apresoline) considerations

A

Max = 40 mg dose
Reflex tachycardia
Caution with CAD patients

28
Q

metoprolol (Lopressor)concentration

A

1 mg/ml

29
Q

Metoprolol (Lopressor) onset

A

2-5 min

30
Q

Metoprolol (Lopressor) duration

A

6-12 hours

31
Q

Metoprolol (Lopressor) metabolization:elimination

A

Hepatic:Renal

32
Q

Betablocker effects

A

Decrease CO, decrease inotropy, decrease HR, decrease MAP, Labetalol: decrease SVR

33
Q

Esmolol (Brevibloc) concentration

A

10 mg/ml

34
Q

Esmolol (Brevibloc) onset

A

2 min

35
Q

Esmolol (Brevibloc) duration

A

9-20 min

36
Q

Esmolol (Brevibloc) metabolism:elimination

A

Nonspecific esterases

37
Q

Nitroprusside (Nipride) concentrations

A

400 mcg/ml

100 mg:250 ml

38
Q

Nitroprusside (Nipride) onset

A
39
Q

Nitroprusside (Nipride) duration

A

1-10 min

40
Q

Nitroprusside (Nipride) metabolism/elimination

A

RBC + Tissue, renal

41
Q

Nitroprusside (Nipride) effects

A

– MAP, – SVR

42
Q

Labetalol (Normodyne) concentration

A

5 mg/ml

43
Q

Labetalol (Normodyne) onset

A

1-2 min

44
Q

Labetalol (Normodyne) duration

A

2-8 hours

45
Q

Labetalol (normodyne) metabolism/elimination

A

Hepatic:renal

46
Q

Nitroglycerin (Nitrol) concentration

A

100 mcg/mL

25 mg/250 ml

47
Q

Nitroglycerin (Nitrol) onset

A

1-2 min

48
Q

Nitroglycerin (Nitrol) duration

A

3-6 hours

49
Q

Nitroglycerin (Nitrol) metabolism/elimination

A

Hepatic/renal

50
Q

Nitroglycerin (Nitrol) effects

A

– preload, - MvO2

51
Q

Nicardipine (Cardene) concentration

A

100 mcg/ml

25 mg/250 ml

52
Q

Nicardipine (Cardene) onset

A

1-5 min

53
Q

Nicardipine (Cardene) duration

A

3-6 hours

54
Q

Nicardipine (Cardene) metabolism:elimination

A

Hepatic:renal

55
Q

Nicardipine (Cardene) effects

A

– MAP, – SVR

56
Q

Hydralazine (apresoline) concentration

A

20 mg/mL

57
Q

Hydralazine (apresoline) onset

A

5-20 min

58
Q

Hydralazine (apresoline) duration

A

4-8 hours

59
Q

Hydralazine (apresoline) metabolism:elimination

A

Hepatic:renal

60
Q

Hydralazine (apresoline) effects

A
  • MAP: - SVR

- PVR

Clinical Pharm (10 decks)

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