Antimetabolites Flashcards Preview

Oncology > Antimetabolites > Flashcards

Flashcards in Antimetabolites Deck (5)
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1
Q

Methotrexate

A
  • Folate antagonist.
  • Used in ALL, Choriocarcinoma, Burkitts lymphoma, Breast cancer. AI disease in low doses.
  • AE: BM suppression, stomatitis, Nephrotoxicity, Hepatic fibrosis, Pneumonitis, Erythema etc.
  • NB, teratogenic.
2
Q

6-Mercaptopurine

A
  • Purine analogue, blocks their biosynthesis + is incorporated into DNA to give nonfunctional DNA.
  • Used in ALL maintenance.
  • AE: BM suppression, Hepatotoxicity
3
Q

Azathioprine

A
  • Purine analogues. Prodrug -> 6-MP.

- Mainly as immunosuppression for RA.

4
Q

5-Fluorouracil

A
  • Pyrimidine analogue (uracil), inhibits thymidine synthase to inhibit DNA synth.
  • IV due to severe GIT toxicity. Crosses BBB.
  • used in Solid tumors
  • AE: GIT tox, Myelosuppression, neurotox
5
Q

Cytosine arabinose (cytarabine)

A
  • Inhib DNA polymerase.
  • Acute leukemias.
  • Myelosuppression, GIT disturbances