Antimicrobial Chemotherapy 3 Flashcards Preview

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Flashcards in Antimicrobial Chemotherapy 3 Deck (24)
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1

What has no action against fungi?

Most antibiotics

2

What are the classes of anti-fungal drugs?

Polyenes

Azoles

Allylamines

Echinocandins

3

How do polyenes act?

Bind to ergosterol in fungal cell wall and creates a pore

Also binds to other sterols such as cholesterol so are toxic

4

Why are polyenes toxic?

They bind to sterols such as cholesterol

5

What are examples of polyenes?

Amphotericin B

Nystatin

6

How do azoles act?

Inhibit the synthesis of ergosterol

7

What are examples of azoles?

Fluconazole

Itraconazole

Voriconazole

8

How do allylamines act?

Supress ergosterol synthesis but act at a different stage of the pathway than azoles (act earlier)

9

What is an example of an allylamine?

Terbinafine

10

How do echinocandins act?

Inhibit the synthesis of glucan polysaccharide

11

What are examples of echinocandins?

Caspofungin

Micafungin

Anidulafungin

12

How would you describe the number of viral diseases that are treatable?

Few are treatable

13

What is there none of in terms of treating viruses?

Virucial agents (kill the virus)

14

What do virucial agents do?

Kill the virus

15

What do virustatic agents do?

Inhibit the growth

16

What are many anti-viral drugs?

Nucleoside analogous which interfere with nucleic acid synthesis

17

What are some anti-viral drugs?

Anti-herpes virus drugs

Anti-HIV drugs

Drugs for chronic hepatitis B and C

Drugs for viral respiratory infections

18

What are some herpes viruses that there are drugs against?

Herpes simplex virus (HSV)

Cytomegalovirus (CMV)

Varicella-zoster virus (VZV)

Epstein-barr virus (EBV)

19

How do anti-HIV drugs work?

Nucleoside analogue interfering with the action of reverse transcriptase (slows down replication)

20

What is a drug used for chronic hepatitis B and C?

Interferon-a is part of the host immune system and is produced by genetic engineering

21

What are some drugs used for the treatment of influenza A or B?

Zanamivir

Oseltamivir

22

What is used for the treatment of respiratory syncytial virus (RSV)?

Ribavirin

23

What is genotype analysis?

Sequencing of part of the viral genome

24

What can genotypic analysis help with?

Choosing the treatment for patients