What has no action against fungi?
What are the classes of anti-fungal drugs?
How do polyenes act?
Bind to ergosterol in fungal cell wall and creates a pore
Also binds to other sterols such as cholesterol so are toxic
Why are polyenes toxic?
They bind to sterols such as cholesterol
What are examples of polyenes?
How do azoles act?
Inhibit the synthesis of ergosterol
What are examples of azoles?
How do allylamines act?
Supress ergosterol synthesis but act at a different stage of the pathway than azoles (act earlier)
What is an example of an allylamine?
How do echinocandins act?
Inhibit the synthesis of glucan polysaccharide
What are examples of echinocandins?
How would you describe the number of viral diseases that are treatable?
Few are treatable
What is there none of in terms of treating viruses?
Virucial agents (kill the virus)
What do virucial agents do?
Kill the virus
What do virustatic agents do?
Inhibit the growth
What are many anti-viral drugs?
Nucleoside analogous which interfere with nucleic acid synthesis
What are some anti-viral drugs?
Anti-herpes virus drugs
Drugs for chronic hepatitis B and C
Drugs for viral respiratory infections
What are some herpes viruses that there are drugs against?
Herpes simplex virus (HSV)
Varicella-zoster virus (VZV)
Epstein-barr virus (EBV)
How do anti-HIV drugs work?
Nucleoside analogue interfering with the action of reverse transcriptase (slows down replication)
What is a drug used for chronic hepatitis B and C?
Interferon-a is part of the host immune system and is produced by genetic engineering
What are some drugs used for the treatment of influenza A or B?
What is used for the treatment of respiratory syncytial virus (RSV)?
What is genotype analysis?
Sequencing of part of the viral genome
What can genotypic analysis help with?
Choosing the treatment for patients