Antineoplastic Agents III, Antimitotic Drugs Flashcards

-Drugs that disrupt microtubule stability and block mitosis.

1
Q

*Vinca alkaloids (class), Members (Vinblastine, vincristine, vinorelbine) MOA and what phase does the drug work in?

A
  • INHIBIT TUBULIN POLYMERIZATION–BLOCK ASSEMBLY of microtubules
  • M-PHASE
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2
Q

*Taxanes (class), Members (Taxol(Paclitaxel) and taxotere (Doccetaxel)) MOA and what phase does the drug work in?

A
  • ENHANCE TUBULIN POLYMERIZATION–STABILIZE microtubules
  • “Taxes stabalize”
  • M-phase
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3
Q

Epothilones (class), members Ixabepilone MOA and what phase does the drug work in?

A
  • Same as Taxanes: ENHANCE tubulin polymerization–STABALIZE microtubules
  • M-phase
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4
Q

*Vinblastine Uses

A

TESTICULAR CANCER (with bleomycin and cisplatin), lymphomas, neuroblastoma

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5
Q

*Vincristine Uses

A

-More pediatric uses: WILM’S AND EWINGS SARCOMA, ALL, lymphoma, neuroblastoma,

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6
Q

Vinorelbine uses

A

-NSCL cancer (alone or with cisplatin)

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7
Q

Paclitaxel uses

A

-Advance breast/ovarian cancer (with cisplatin)

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8
Q

Docetaxel uses

A

-Advance breast/ovarian cancer, solid tumors (low yield?)

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9
Q

Epothilone Uses

A

-Resistant breast cancer (alone or with capecitabine)

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10
Q

Vinblastine Dose limiting Toxicity

A
  • Bone marrow suppression

- Vesicant blisters

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11
Q

Vincristine Dose limiting Toxicity

A
  • Neurotoxicity
  • Peripheral neuropathy
  • Paralytic ileus
  • Vesicant -blisters
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12
Q

Vinorelbine Dose limiting Toxicity

A
  • Bone marrow suppression

- Vesicant -blisters

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13
Q

Paclitaxel Dose limiting Toxicity

A
  • Bone marrow suppression, Peripheral neuropathy

- Hypersensitivity during infusion:anti-histamine needed and corticosteroid pretreatment

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14
Q

Docetaxel Dose limiting Toxicity

A

-Neutropenia, Peripheral neuropathy

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15
Q

Epothilone Dose limiting Toxicity

A
  • Myelosuppression, peripheral neuropathy

- hypersensitivity

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16
Q

Vanco, taxanes, epothilone resistance developed how?

A

-P-glycoprotein transporter or by tubulin mutation