Antiprotozoal Drugs Flashcards Preview

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Flashcards in Antiprotozoal Drugs Deck (5)
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1
Q

What is Hemozoin?

A

A byproduct of heme digestion by malaria, insoluble non-toxic crystals

2
Q

What do Quinine and Chloroquine do?

A

(tonic water)

Accumulate in digestive vesicles of Plasmodium and inhibit heme polymerase (prevents hemozoin formation)

3
Q

What is artesunate?

A

Semisynthetic prodrug, interferes with hemoglobin metabolism by producing free radicals

4
Q

Which two antibacterial drugs can be used as antimalarial drugs?

A

Doxycycline (tetracycline)
azithromycin (macrolide)

They target ribosomes within parasite mitochondria

(can also affect human mitochondria)

5
Q

What are the two stages of malaria’s life cycle, and where is each cycle located in its host(s)?

A

Asexual reproductive phase: human liver blood cells

Sexual phase:
mosquito salivary glands/gut