Antiprotozoan therapy Flashcards Preview

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Flashcards in Antiprotozoan therapy Deck (14)
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1
Q

Patient has toxoplasmosis, what is treatment of choice?

A

Pyrimethamine + sulfadiazine

2
Q

Patient has Trypanosmoa brucei, what is treatment of choice?

A

suramin (blood) and melarsoprol (cns)

3
Q

Patient has T. cruzi, what is treatment of choice?

A

nifurtimox or benznidazole

4
Q

Chloroquine mech

A

Block detoxification of heme into hemozoin. Heme accumulates and is toxic to plasmodia

5
Q

Chloroquine is used to treat all plasmodium species except which one? why? how?

A

P. falciparum; frequency of resistance too high; membrane pump that decreases intracellular concentration of drug.

6
Q

What is the treatment of P. Falciparum?

A

artemether/lumefantrine OR atovaquone/proguanil.

7
Q

Treatment for giardiasis?

A

Tinidazole or metronidazole

7
Q

Treatment for giardiasis?

A

Tinidazol

8
Q

Treatment for entamoeba histolytica

A

Metronidazole, iodoquinol for asymptomatic cyst passers

9
Q

Treatment for cryptosporidium

A

Prevention by filtering city water supplies. Nitazoxanide in immunocompetent hosts

10
Q

Treatment for naegleria fowleri

A

Amphotercin B

11
Q

Leishmania donovani

A

Amphotericin B, sodium stibogluconate

12
Q

Babesia

A

Atovaquone + azithromycin

13
Q

Plasmodium treatment

A

1) Begin with chloroquine, which blocks plasmodium heme polymerase 2) if resistant use mefloquine or atovaquone/proguanil 3) if life threatening use IV quinidine (test for G6PD deficiency) 4) for P vivax/ovale: add primaquine for hypnozoite (test for G6PD deficiency)