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Flashcards in Antiviral mechanisms Deck (8)
1

Aciclovir

Inhibits DNA polymerase (nucleoside analogue)

used in HSV, VZV

Causes crystalline nephropathy

As going up Herpesvirus 1-2-6-7-8 etc need higher doses to kill

2

Ganciclovir

Inhibits DNA polymerase

used in CMV

Causes myelosupression/agranulocytosis

3

Ribavirin

Guanosine analogue which inhibits inosine monophosphate dehydrogenase to interfere with capping of viral mRNA

Used in Hep C and Ribavirin

Causes haemolytic anaemia

4

Oseltamivir

Neruaminidase inhibitor - prevent release/budding of new virions

used in Flu A and B

5

Amantadine
Rimantadine

M2 inhibitor
Blocks uncoating

For Flu A only

6

Interferon

blocks mRNA translation somehow
Not too well understood

7

Why give valaciclovir over aciclovir?

Better bioavailability
Famciclovir even higher bioavaiability

8

Foscarnet

Phosphorylate analogue- inhibits DNA polymerase

Use in CMV retinitis in HIV
HIV patients with aciclovir resistant HSV