Antiviral Medchem Flashcards Preview

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Flashcards in Antiviral Medchem Deck (16)
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0
Q

Cidfovir ganciclovir foscarnet

A

DNA polymerase

Foscarnet mimic pyrophosphate

1
Q

Acyclovir

A

Thymidine kinase

2
Q

Amantadine

Rimantidine

A

Block M2 uncoating of virus particle and release of viral RNA

3
Q

Zanamivir

Oseltamivir

A

Transition state inhibitor of neuraminidase/sialidase

4
Q

Ribavirin hep C

A

Inhibit inosine mono phosphate dehydrogenase

Cause decrease in GTP

5
Q

DNA viruses

A

HSV, Varicella zoster, HepB

6
Q

RNA viruses

A

HIV, influenza, HepACE

7
Q

Bocepravir, telaprevir

A

Inhibit hepC serine protease

8
Q

Maraviroc (selzentry)

A

Chemokine receptor CCR5 antagonist

9
Q

Enfuviritide (fuzeon)

A

Mimic gp41 HR-2 needed for viral fusion zipping

10
Q

Quinolines: chloroquine, mefloquine

A

Interfere with hemoglobin/heme

11
Q

Atovaquine + proguanil (malarone)

A

Inhibit dihydrofolate reductase DHFR

12
Q

Artemisinin

A

Endoperoxide o-o free radical

13
Q

Free radical mechanism

A

Artemisinin, metronidazole, isoniazid,

14
Q

Rifamycin

A

Block RNA polymerase

15
Q

Pyrazinamide

A

Interfere with NAD synthesis