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Flashcards in Antivirals Deck (22)
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1

Tropism of viral hepatitis

Liver hepatocytes

2

Treatment for Hep B

tenofovir- goal is to 100% cure

3

MOA tenofovir

Nucleotide analogue

4

Hep C treatment

Ribavirin- purine analogue
Boceprevir- PI

5

Important steps in life cycle of HIV

Attachment and entry- viral membrane proteins interact with leukocyte membrane receptors- then is endocytosis of viral capsid
Replication and integration- within cytoplasm reverse transcriptase converts RNA to DNA which is transported to nucleus and integrated into host DNA
Assembly and release-host cell machinery used to produce viral RNA and essential proteins
These proteins are assembled and mature virion is released

6

How does HIV attach to leukocyte

Viral GP120 binds to CD4 receptor and also CCR5 or CXCR4 as a co-receptor

7

How does HIV enter cell

GP41 penetrates cell membrane and viral capsid enters

8

2 drugs used to treat HIV cel entry

Enfuvirtide- binds to HIV GP41 transmembrane glycoprotein
Maraviroc- blocks CCR5

9

Reverse transcription of HIV RNA

Viral single-stranded RNA-> double stranded DNA by reverse transcriptase

10

3 drugs used to treat HiIV replication

Zidovudine- nucleoside RT inhibitor
Tenofovir- nucleotide RT inhibitor
Efavirenz- inhibts enzyme directly witout being incorporated into viral DNA

11

Role of viral integrase

Inserts viral DNA into host DNA

12

Drug that inhibits integrase

Raltegravir

13

Difference between zidovudine and tenofovir to efavirenz

Zidovudine and tenofovir require phosphorylation unlike efavirenz
Zidovudine> tenofovir in terms of phosphorylation required

14

What is gag precursor

Encodes all viral structural proteins

15

What is role of HIV protease

Cleaves Gag precursor protein

16

2 examples of protease inhibitors

Saquinavir
Ritonavir- this is low does booster

17

Features of HSV virus

DsDNA
Surrounded by tegument and lipid bilayer

18

Treatment for HSV

Acyclovir- nucleoside analogue

19

Features of influenza genetic material

ssRNA

20

What is important influenza envelope protein

Neuraminidase- important in release

21

Treatment for influenza

Oseltamivir- inhibits neuraminidase

22

Tropism for influenza

Bronchi
Throat
Nose