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Rheumatology > Autoantibodies Test > Flashcards

Flashcards in Autoantibodies Test Deck (22)
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1
Q

RhF - Rheumatoid factor

A
Sjögren's 100%
Felty's syndrome 100% (rheumatoid arthritis, splenomegaly, leukopenia)
RA 70%
Infection 50%
Mixed connective tissue disease 50%
SLE 40%
Systemic sclerosis 30%
2
Q

Anti CCP - anticyclic citrullinated peptide Ab

A

Rheumatoid arthritis RA 96% specificity

3
Q

ANA - antinuclear antibody (positive by immunofluorescence)

A

SLE >95%
Autoimmune hepatitis 75%
Sjögren’s 68%
RA 30%

4
Q

What is the pattern of staining for ANA in different diseases?

A

Homogenous - SLE
Speckled - Mixed connective tissue disease
Nucleolar - Systemic sclerosis
Contromere - Limited (cutaneous) systemic sclerosis

5
Q

anti dsDNA - double stranded DNA

A

SLE - 60% sensitive but highly specific

6
Q

Antihistone Ab

A

Drug induced SLE - around 100%
Examples: Isoniazid, hydralazine (in slow acetylators), procainamide, quinidine, chlorpromazine, minocycline, phenytoin.

Skin and lung signs prevail, disease remits if drug is stopped.

Sulphonamides and OCP may worsen idiopathic SLE

7
Q

Antiphospholipid Ab

A

Antiphospholipid syndrome, SLE

8
Q

Anticentromere Ab

A
Limited (cutaneous) systemic sclerosis (CREST syndrome) 70-80%
C - Calcinosis (subcutaneous tissue)
R - Reynaud's
E - oEsophageal and gut dysmotility
S - Sclerodactyly
T - Telangectasia

Skin involvement is limited to the hands face and feet
Pulmonary hypertension is often present subclinically and can progress rapidly - treat with sildenafil, bosentan

9
Q

Anti ENA - Extractable nuclear antigen Ab

A

Anti-Ro: SLE, Sjögren’s, systemic sclerosis (associated with congenital heart block)
Anti-La: Sjögren’s, SLE (15%)
Anti-Sm: SLE (20-30%)
Anti-RNP: SLE, mixed connective tissue disorder
Anti-Jo / Mi-2: Polymyositis, dermatomyositis
Anti-Scl70 (topoisomerase-1): Diffuse systemic sclerosis

10
Q

AMA - Antimitochondrial Ab

A

Primary biliary sclerosis 95%

Autoimmune hep 30%

11
Q

SMA - anti-smooth muscle Ab

A

Autoimune Hepatitis 70%

Primary Biliary Sclerosis 50%

12
Q

Gastri parietal cell Ab

A

Pernicious anaemia 90%
Atrophic gastritis 40%
“Normal” 10%

13
Q

Intrinsic Factor Ab

A

Pernicious anaemia 50%

14
Q

Alpha-gliadin, antitissue transglutaminase, anti-endomysial Abs

A

Ceoliac disease

15
Q

Thyroid Peroxidase Ab

A

Hashimoto’s thyroiditis 87%

Grave’s 50%

16
Q

ICA - Islet cell Ab

GAD - Glutamic acid decarboxylase

A

Type 1 DM (75%)

17
Q

GBM Ab - Glomerular Basement Membrane Ab

A

Goodpasture’s 100%

18
Q

ANCA - Anti neutrophil cytoplasmic antibody

A

cytoplasmic “cANCA” - Granulomatosis with polyangiitis (Wegener’s) 90%
peripheral “pANCA” - Microscopic polyangiitis 45%

Known as ‘pauci-immune’ vasculaitis as there is no involvement of immune complexes or complement consumption

19
Q

ACh receptor antibody

A

Myasthenia Gravis 90%

20
Q

Anti-voltage-gated K channel Ab

A

Limbic encephalitis

21
Q

Anti-voltage-gated Ca channel Ab

A

Lambert-Eaton Syndrome

22
Q

Anti-aquaporin 4 Ab

A

Neuromyelitis optica