B16 synthetic and semisynthetic opiates Flashcards Preview

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Flashcards in B16 synthetic and semisynthetic opiates Deck (3)
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1
Q

What is a semisynthetic opioid?

List them

A

A structural derivative of the 3 natural opiates: morphine, codeine, and thebaine.

Morphine derivatives:

  • Dihydromorphone, Hydromorphone, Dilaudid
  • Heroin, Diacetylmorphine
  • Ethylmorphine - decreased potency, similar to codeine
  • Oxymorphone - increased potency
  • Nalorphine - mu antagonist, very strong K-agonist not used.
  • Naltrexone - oral antagonist. (competivitve)
  • Naloxone - iv antagonist

Codeine derivatives:

  • Dihydrocodeine
  • Dihydrocodone
  • Oxycodone

Thebaine derivatives;

  • Buprenorphine
  • Nalbuphine
2
Q

What are the synthetic opioids

A
Fentanyl, Sufentanil, Alfentanil, Remifentanil
Meperidine
Methadone
Tapentadol
Tramadol

Pentazocine
Butrophanol
Pentazocine

Dextromethorphan
Loperamide
Diphenoxalate

3
Q

Hydromorphone and Hydrocodone relative potency to morphine

A

Dilaudid ~10 times more potent.