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Flashcards in Biochemistry- K+ Deck (13)
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1
Q

Why is maintaining potassium concentration so vital?

A

Pottasium helps set up the resting membrane potential of cells, so changing its concentration can lead to excitability of cells e.g. nerve and heart cells.

2
Q

What are the two most important factors that affect potassium excretion?

A

Glomerular filtration rate

Plasma potassium concentration.

3
Q

Where is potassium lost from?

A

A small amount lost from the gut (5mmol/day)

Rest from the kidneys.

4
Q

What factor, other than increased excretion, can affect potassium balance?

A

Redistribution of potassium. Most of the bodies potassium (98%) is inside the cell. If there is significant tissue damage, this potassium can go elsewhere, disturbing the balance.

5
Q

When is hyperkalaemia thought to be severe?

A

When the potassium levels >7mmol- this is immediately life threatening.

6
Q

What ECG changes may you see in hyperkalaemia?

A

Tall ‘tented’ T waves
Widening of the QRS complex
(This reflects altered myocardial contractility).

7
Q

What other symptoms may you get with hyperkalaemia?

A

Muscle weakness

Parathesia (reflecting impact of K+ on muscles and nerves).

8
Q

How can hyperkalaemia be categorised?

A

Increased intake
Redistribution
Decreased excretion

9
Q

Why may you get reduced excretion causing hyperkalaemia?

A

Renal failure-reduced GFR means the kidneys can’t excrete pottasium.
Hypoaldosteronism-Aldosterone stimulates sodium reabsorption in the distal tubules in return for excreting potassium and hydrogen. This is most often due to use of ACE inhibitors and ARBs

10
Q

What causes redistribution of potassium?

A

Potassium release from damaged cells- occurs in rhabdomyalsis, tumour lysis syndrome.

Metabolic acidosis- There is a relationship between conc of H+ ions and potassium. As H+ increases, it displaces potassium from inside the cell.

Insulin deficiency- Insulin stimulates cellular uptake of potassium. If there is insulin deficiency or resistance, hyperkalaemia can ensue.

Hyperkalaemic periodic paralysis- rare family disorder. Presents as frequent attacks of muscle weakness or paralysis.

11
Q

What are the causes of increased intake of pottasium?

A

Many drugs are given as potassium salts.

Sometimes blood products give excess potassium.

12
Q

How quickly can IV potassium be given?

A

Should not be given at greater than 20mmol/ hour except in extreme cases.

13
Q

How do you treat hyperkalaemia?

A

Calcium gluconate- counteracts the effects of hyperkalaemia on resting membrane potentials
Insulin and glucose- to promote uptake of potassium by tissues.
Look for underlying cause of reduction in GFR.