Carbemazepine Flashcards Preview

Pharmacology - Nervous system > Carbemazepine > Flashcards

Flashcards in Carbemazepine Deck (9)
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1
Q

What is carbemazepine indicated for use in?

A
  • Epilepsy
  • Trigeminal neuralgia
  • Bipolar Disorder
2
Q

What is the mechanism of action of carbamazepine?

A

Appears to inhibit neuronal sodium channels, stabilising resting membrane potentials and reducing neuronal excitability. This may inhibit spread of seizure activity in epilepsy, control neuralgic pain and stabilise mood in bipolar disorder

3
Q

How does carbemazepine stabilise mood in bipolar disorder?

A

Reducing electrical kindling in the temporal lobe and limbic system

4
Q

How does carbemazepine block pain with trigeminal neuralgia?

A

Blocks synaptic transmission in the trigeminal nucleus

5
Q

What are important adverse side effects of carbemazepine?

A
  • GI upset
  • Dizziness
  • Ataxia
  • Hypersensitivity
  • SJS/TEN
  • Fever
  • lymphadenopathy
  • Oedema
  • Hyponatraemia
6
Q

What considerations do you need to take into account with regard to carbemazepine interacting with other drugs?

A
  • Cytochrome P450 inducer
  • Cytochrome P450 inducers increase its effects
7
Q

What do you need to warn individuals with regards to taking carbemazepine?

A

Look out for:

  • Skin rashes
  • Bruising
  • Bleeding
  • High temp
  • Mouth ulcers
  • Reduced appetite/abdo pain
8
Q

How would you monitor carbemazepine use?

A

Symptoms

9
Q

What type of seizure is carbemazepine regarded as first line treatment for?

A

Focal Seizures