Cardio - Heart Failure Flashcards Preview

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Flashcards in Cardio - Heart Failure Deck (9)
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1
Q

What is the qualification for left ventricular reduced EF

A

LVEF < 50%

2
Q

Systolic failure results in which changes

A
  • Loss of inotropy (Decreased ESPVR slope) (Decreased SV and EF
  • Ventricular remodeling and dilation (Increased ESV and EDV)
3
Q

What does the pressure volume curve look like in systolic failure

A

Moves to the right

4
Q

What are the changes seen in diastolic failure

A

Decreased compliance:

  • Increased EDPVR slope
  • Increased ED pressure
  • Decreased EDV
5
Q

What does the pressure pressure volume curve look like in diastolic failure

A

Moved to the left

6
Q

What is the resulting EDV following an MI

A

Increased in the LVEDV

7
Q

What is the metabolism of captopril

A

Substrate for CYP2D6

8
Q

What is the substrate for losartan

A

CYP 2C9 and 3A4

9
Q

What is the relation of aldosterone to damage heart vasculature

A

Damaged heart vasculature produces aldosterone after an MI, and induced fibrosis