Cell Mediated Toxicity

Question 1

name the 3 mechanisms of death that CTL and NK cells use

Answer 1

cytotoxic granule release
fas-fas ligand interactions
TNF
all lead to caspase and apotosis

Question 2

Name some differences between a naive and mature CTL

Answer 2

Naive do not have IL-2/IL-2R
not cytotoxic
no granules
Mature talk to MHC Class I

Question 3

NK cells lack these forms of specialization that CTL perform

Answer 3

Education

Rearrangement

Question 4

What cytokines can acitvate NK cells?

Answer 4

INF alpha, beta, and gamma
TNF alpha
IL-15

Question 5

Instead of binding MHC Class I, NKT cells bind these glycoplipids

Answer 5

CD1d

Question 6

Cytotolic enzyme release is initated when an immune complex binds with one these 3 cells

Answer 6

macrophage
eosinophils
neutrophils

Question 7

name the 2 type of NK receptors

Answer 7

lectin

immunoglobulin

Question 8

Effector molecules are the same for CTL and NK cells. Name some of them..

Answer 8

cytotoxins (perferin, granzymes)
INFgamma
TNF
fas ligand

Question 9

NKT cells mechanism of death involves faf-fas ligand and this activation

Answer 9

activation of NK cells

Question 10

In order to mature, a naive CTL requires these signals.

Answer 10

MHC complex and CD 28/B7 binding via MCH I

IL-2

Question 11

Cells target other cells when they behave or look weird. What are some of the weird things they might display?

Answer 11

Recognize non-self, stress induced ligands, or missing self recognition

Question 12

Memory cells can act very quickly because they do not require this step to begin their work

Answer 12

Activation via Cd4+/TH1

Question 13

Describe a KIR

Answer 13

NK receptor that is immunoglobulin like and binds an MHC-1

Question 14

Binding of immune complex to NK, monocytes and macros result in the release of this cytokine

Answer 14

TNF