Cellular Physiology Flashcards Preview

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Flashcards in Cellular Physiology Deck (17)
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1
Q

Disk-shaped structure for tight intercellular adhesion.

A

macula adherens / desmosomes

2
Q

Ribbon-like patterns (structures) in cardiomyocytes which increase surface area for contact with adjacent cells.

A

fascia adherens

equivalent of zonula adherens

3
Q

Identify the following tight junctions if leaky or tight:

a. proximal collecting tubule
b. jejunum
c. collecting duct
d. terminal colon
e. blood-brain barrier

A

leaky: PCT, jejunum
tight: CD, terminal colon, BBB

4
Q

Recite the Fick’s law of diffusion.

A

J = PA (C1-C2)

5
Q

Which of the following will decrease the permeability of a solute through a semi-permeable membrane?

a. decreased oil-water partition coefficient
b. decreased radius of solute
c. decreased membrane thickness
d. NOTA
e. AOTA

A

A. A decrease in partition coefficient will decrease the solubility of the solute in the lipid of the membrane.

Review Fick’s law of diffusion.

6
Q

Doubling the area of the membrane and tripling the concentration gradient will

a. not affect the flux
b. double the flux
c. triple the flux
d. 6x the flux
e. 2/3 the flux

A

D. 6x the flux

J = P x A x (C1-C2)
J' = P x 2A x 3(C1-C2)
J' = 6J
7
Q

Enumerate the three characteristics of carrier-mediated transport.

A

stereospecificity
saturation
competition

8
Q

At high-solute concentration, facilitated diffusion will be _____ compared simple diffusion.

a. similar
b. slower
c. faster
d. NOTA

A

B. slower

At higher concentration, carrier proteins will be saturated hence facilitated diffusion will be slower.

9
Q

The SERCA protein transfers calcium from the ____ to the ____.

A

from the cytosol to the sarcoplasmic reticulum

10
Q

MOA of digoxin

A

inhibits Na-K-ATPase pump > inhibits Na-Ca pump > increase in intracellular calcium > greater cardiac contractility

11
Q

The reflection coefficient of albumin is

a. >1
b. 1
c. <1
d. 0
e. undefined

A

B. 1

The reflection coefficient (RC) is a number between zero and one which describes the ease by which a particular solute permeates a membrane

1 = no penetration (all are reflected)
0 = complete penetration (none reflected)
12
Q

The cell membrane resting potential is approximately

A

-70 mV

13
Q

Conduction velocity of an action potential is most dependent on

A

nerve diameter

14
Q

A nervous system tissue macrophage that act as scavenger cell which removes debris

A

microglia

15
Q

Which of the following forms myelin in the peripheral nervous system?

a. Schwann cells
b. oligodendrocytes
c. astrocytes
d. fibrocytes
e. protoplasmic astrocytes

A

A. Schwann cells

oligodendrocytes - macroglia that forms myelin in CNS
astrocytes - macroglia acting as nurse cells
fibrocytes - astrocytes in the white matter
protoplasmic astrocytes - astrocytes in the gray matter

16
Q

Where does the action potential start?

A

at the initial segment of the axon

17
Q

Autoimmune disease that attacks myelin resulting in demyelination

A

multiple sclerosis