Cervical cancer Flashcards

1
Q

70% of cervical cancers are caused by which HPV

A

16 + 18

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2
Q

HPV 6 + 11 responsible for ?

A

genital warts

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3
Q

HPV vaccine covers for____-

A

16, 18, 6, 11

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4
Q

most common cancer in women under 35

A

cervical cancer

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5
Q

vaccine is offered to who

A

girls at age 12-13

catch up available up to 18 years of age

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6
Q

how is the vaccine given

A

series of 2 injections; spaced at least 6 months apart

however if offered older than 15; require 3 injections with the second being given at least a month after the first

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7
Q

what is the cervical screening offered

A

every 3 years between 25 and 49 years

every 5 years between 50 and 64 years

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8
Q

what is brachytherapy

A

uses a radioactive source inserted via an applicator into the vagina/cervix; delivering a higher dose to the tumour with less toxicity to surrounding organs

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9
Q

4 cisplatin toxicities

A
  • peripheral neuropathy
  • hearing impairment
  • bone marrow suppression
  • renal impairment
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10
Q

risk factors for cervical cancer

A
  • multiple sexual partners
  • HPV infection
  • early onset of sexual activity
  • immunosuppression
  • 45 to 59 years
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11
Q

symptoms of cervical cancer (although typically late signs )

A
  • abnormal vaginal bleeding
  • postcoital bleeding
  • mucoid/purulent vaginal discharge
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12
Q

management of cervical cancer in pregnancy

A

MDT

delivery at 35 weeks

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13
Q

CIN I

A

low grade lesion with mildly atypical cellular chamnge in lower 1/3 epithelium

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14
Q

CIN II

A

high grade lesion with moderately atypical cellular changes confined to basal 2/3 epithelium

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15
Q

CIN III

A

severely atypical cellular changes encompassing greater than 2/3 of epithelial thickness and includes full thickness lesions
(severe dysplasia or CIS)

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16
Q

CIS

A

carcinoma in situ